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Thursday 25 August 2016

TO LOVE OR NOT TO LOVE - THE MOST COMMON USED WORD ON SOCIAL MEDIA




TO LOVE OR NOT TO LOVE

LOVE  

THE MOST COMMON USED WORD ON SOCIAL MEDIA


Stes de Necker




Love is one of the most profound emotions known to human beings.

There are many kinds of love, but most people seek its expression in a romantic relationship with a compatible partner. For some, romantic relationships are the most meaningful element in their lives, providing a source of deep fulfilment.

The ability to have a healthy, loving relationship is not innate. A great deal of evidence suggests that the ability to form a stable relationship begins in infancy, in a child's earliest experiences with a caregiver who reliably meets the infant's needs for food, care, protection, stimulation, and social contact. Those relationships are not destiny, but they appear to establish patterns of relating to others. Failed relationships happen for many reasons, and the failure of a relationship is often a source of great psychological anguish. Most of us have to work consciously to master the skills necessary to make them flourish.

Abstractly discussed love usually refers to an experience one person feels for another.

Love often involves caring for or identifying with a person or thing (cf. vulnerability and care theory of love), including oneself (cf. narcissism). In addition to cross-cultural differences in understanding love, ideas about love have also changed greatly over time.

Some historians date modern conceptions of romantic love to courtly Europe during or after the Middle Ages, although the prior existence of romantic attachments is attested by ancient love poetry.
The complex and abstract nature of love often reduces discourse of love to a thought-terminating cliché. Several common proverbs regard love, from Virgil's  "Love conquers all "  to The Beatles' "All You Need Is Love". St. Thomas Aquinas, following Aristotle, defines love as "to will the good of another." 

Bertrand Russell describes love as a condition of "absolute value," as opposed to relative value. Philosopher Gottfried Leibniz said that love is "to be delighted by the happiness of another." Meher Baba stated that in love there is a "feeling of unity" and an "active appreciation of the intrinsic worth of the object of love." Biologist Jeremy Griffith defines love as "unconditional selflessness".

Impersonal love

A person can be said to love an object, principle, or goal to which they are deeply committed and greatly value.

For example, compassionate outreach and volunteer workers' "love" of their cause may sometimes be born not of interpersonal love but impersonal love, altruism, and strong spiritual or political convictions. 

People can also "love" material objects, animals, or activities if they invest themselves in bonding or otherwise identifying with those things. If sexual passion is also involved, then this feeling is called paraphilia.

Interpersonal love

Interpersonal love refers to love between human beings. It is a much more potent sentiment than a simple liking for another. Unrequited love refers to those feelings of love that are not reciprocated.
Interpersonal love is most closely associated with interpersonal relationships. Such love might exist between family members, friends, and couples. There are also a number of psychological disorders related to love, such as erotomania.

Throughout history, philosophy and religion have done the most speculation on the phenomenon of love. In the 20th century, the science of psychology has written a great deal on the subject. In recent years, the sciences of psychologyanthropologyneuroscience, and biology have added to the understanding the concept of love.

Biological basis

Biological models of sex tend to view love as a mammalian drive, much like hunger or thirst

Helen Fisher, a leading expert in the topic of love, divides the experience of love into three partly overlapping stages: lust, attraction, and attachment.

Lust is the feeling of sexual desire; romantic attraction determines what partners mates find attractive and pursue, conserving time and energy by choosing; and attachment involves sharing a home, parental duties, mutual defence, and in humans involves feelings of safety and security. Three distinct neural circuitries, including neurotransmitters, and three behavioural patterns, are associated with these three romantic styles.

Lust is the initial passionate sexual desire that promotes mating, and involves the increased release of chemicals such as testosterone andestrogen.

These effects rarely last more than a few weeks or months. 

Attraction is the more individualized and romantic desire for a specific candidate for mating, which develops out of lust as commitment to an individual mate forms.

Recent studies in neuroscience have indicated that as people fall in love, the brain consistently releases a certain set of chemicals, including the neurotransmitter hormonesdopaminenorepinephrine, and serotonin, the same compounds released by amphetamine, stimulating the brain's pleasure center and leading to side effects such as increased heart rate, loss of appetite and sleep, and an intense feeling of excitement.

Research has indicated that this stage generally lasts from one and a half to three years.

Since the lust and attraction stages are both considered temporary, a third stage is needed to account for long-term relationships. Attachment is the bonding that promotes relationships lasting for many years and even decades. Attachment is generally based on commitments such as marriage and children, or on mutual friendship based on things like shared interests.
It has been linked to higher levels of the chemicals oxytocin and vasopressin to a greater degree than short-term relationships have. 

Enzo Emanuele and coworkers reported the protein molecule known as the nerve growth factor (NGF) has high levels when people first fall in love, but these return to previous levels after one year.

Psychological basis

Psychology depicts love as a cognitive and social phenomenon. 

Psychologist Robert Sternberg formulated a triangular theory of love and argued that love has three different components: intimacy, commitment, and passion.

Intimacy is a form in which two people share confidences and various details of their personal lives, and is usually shown in friendships and romantic love affairs.

Commitment, on the other hand, is the expectation that the relationship is permanent.

The last and most common form of love is sexual attraction and passion. Passionate love is shown in infatuation as well as romantic love. All forms of love are viewed as varying combinations of these three components.

Non-love does not include any of these components. Liking only includes intimacy. Infatuated love only includes passion. Empty love only includes commitment. Romantic love includes both intimacy and passion. Companionate love includes intimacy and commitment. Fatuous love includes passion and commitment. Lastly, consummate love includes all three. 

American psychologist Zick Rubin sought to define love by psychometrics in the 1970s. His work states that three factors constitute love: attachment, caring, and intimacy.

Following developments in electrical theories such as Coulomb's law, which showed that positive and negative charges attract, analogs in human life were developed, such as "opposites attract". Over the last century, research on the nature of human mating has generally found this not to be true when it comes to character and personality—people tend to like people similar to themselves.

However, in a few unusual and specific domains, such as immune systems, it seems that humans prefer others who are unlike themselves (e.g., with an orthogonal immune system), since this will lead to a baby that has the best of both worlds. In recent years, various human bonding theories have been developed, described in terms of attachments, ties, bonds, and affinities.

Some Western authorities disaggregate into two main components, the altruistic and the narcissistic.
This view is represented in the works of Scott Peck, whose work in the field of applied psychology explored the definitions of love and evil. Peck maintains that love is a combination of the "concern for the spiritual growth of another," and simple narcissism. 

In combination, love is an activity, not simply a feeling.

Psychologist Erich Fromm maintained in his book The Art of Loving that love is not merely a feeling but is also actions, and that in fact, the "feeling" of love is superficial in comparison to one's commitment to love via a series of loving actions over time. In this sense, Fromm held that love is ultimately not a feeling at all, but rather is a commitment to, and adherence to, loving actions towards another, oneself, or many others, over a sustained duration. Fromm also described love as a conscious choice that in its early stages might originate as an involuntary feeling, but which then later no longer depends on those feelings, but rather depends only on conscious commitment.

Evolutionary basis

Evolutionary psychology has attempted to provide various reasons for love as a survival tool.
Humans are dependent on parental help for a large portion of their lifespans compared to other mammals. Love has therefore been seen as a mechanism to promote parental support of children for this extended time period. Another factor may be that sexually transmitted diseases can cause, among other effects, permanently reduced fertility, injury to the fetus, and increase complications during childbirth. This would favour monogamous relationships over polygamy.

Comparison of scientific models

Biological models of love tend to see it as a mammalian drive, similar to hunger or thirst
Psychology sees love as more of a social and cultural phenomenon. Certainly love is influenced by hormones (such as oxytocin), neurotrophins (such as NGF), and pheromones, and how people think and behave in love is influenced by their conceptions of love.

The conventional view in biology is that there are two major drives in love: sexual attraction and attachment. Attachment between adults is presumed to work on the same principles that lead an infant to become attached to its mother. The traditional psychological view sees love as being a combination of companionate love and passionate love. Passionate love is intense longing, and is often accompanied by physiological arousal (shortness of breath, rapid heart rate); companionate love is affection and a feeling of intimacy not accompanied by physiological arousal.

Christianity

The Christian understanding is that love comes from God. The love of man and woman—eros in Greek—and the unselfish love of others (agape), are often contrasted as "ascending" and "descending" love, respectively, but are ultimately the same thing.

There are several Greek words for "love" that are regularly referred to in Christian circles.

Agape: In the New Testament, agapē is charitable, selfless, altruistic, and unconditional. It is parental love, seen as creating goodness in the world; it is the way God is seen to love humanity, and it is seen as the kind of love that Christians aspire to have for one another.

Phileo: Also used in the New Testament, phileo is a human response to something that is found to be delightful. Also known as "brotherly love."

Two other words for love in the Greek languageeros (sexual love) and storge (child-to-parent love), were never used in the New Testament.

Christians believe that to Love God with all your heart, mind, and strength and Love your neighbour as yourself are the two most important things in life (the greatest commandment of the Jewish Torah, according to Jesus; cf. Gospel of Mark chapter 12, verses 28–34). 
Saint Augustine summarized this when he wrote "Love God, and do as thou wilt."

The Apostle Paul glorified love as the most important virtue of all. Describing love in the famous poetic interpretation in 1 Corinthians, he wrote, "Love is patient, love is kind. It does not envy, it does not boast, it is not proud. It is not rude, it is not self-seeking, it is not easily angered, it keeps no record of wrongs. Love does not delight in evil but rejoices with the truth. It always protects, always trusts, always hopes, and always perseveres." (1 Cor. 13:4–7, NIV)

The Apostle John wrote, "For God so loved the world that he gave his one and only Son, that whoever believes in him shall not perish but have eternal life. For God did not send his Son into the world to condemn the world, but to save the world through him." (John 3:16–17, NIV) John also wrote, "Dear friends, let us love one another for love comes from God. Everyone who loves has been born of God and knows God. Whoever does not love does not know God, because God is love." (1 John 4:7–8, NIV)

Saint Augustine says that one must be able to decipher the difference between love and lust. Lust, according to Saint Augustine, is an overindulgence, but to love and be loved is what he has sought for his entire life. He even says, “I was in love with love.” 

Finally, he does fall in love and is loved back, by God. Saint Augustine says the only one who can love you truly and fully is God, because love with a human only allows for flaws such as “jealousy, suspicion, fear, anger, and contention.” According to Saint Augustine, to love God is “to attain the peace which is yours.” (Saint Augustine's Confessions)

Augustine regards the duplex commandment of love in Matthew 22 as the heart of Christian faith and the interpretation of the Bible.

After the review of Christian doctrine, Augustine treats the problem of love in terms of use and enjoyment until the end of Book I of De Doctrina Christiana(1.22.21-1.40.44;).

Christian theologians see God as the source of love, which is mirrored in humans and their own loving relationships. Influential Christian theologian C.S. Lewis wrote a book called The Four LovesBenedict XVI wrote his first encyclical on "God is love". He said that a human being, created in the image of God, who is love, is able to practice love; to give himself to God and others (agape) and by receiving and experiencing God's love in contemplation (eros). This life of love, according to him, is the life of the saints such as Teresa of Calcutta and the Blessed Virgin Mary and is the direction Christians take when they believe that God loves them.

In Christianity the practical definition of love is best summarised by St. Thomas Aquinas, who defined love as "to will the good of another," or to desire for another to succeed. This is the explanation of the Christian need to love others, including their enemies. As Thomas Aquinas explains, Christian love is motivated by the need to see others succeed in life, to be good people.

Regarding love for enemies, Jesus is quoted in the Gospel of Matthew chapter five:
“You have heard that it was said, ‘Love your neighbour and hate your enemy.’ But I tell you, love your enemies and pray for those who persecute you, that you may be children of your Father in heaven.  He causes his sun to rise on the evil and the good, and sends rain on the righteous and the unrighteous. If you love those who love you, what reward will you get? Are not even the tax collectors doing that? And if you greet only your own people, what are you doing more than others? Do not even pagans do that? Be perfect, therefore, as your heavenly Father is perfect.” - Matthew 5: 43-48

Tertullian wrote regarding love for enemies: “Our individual, extraordinary, and perfect goodness consists in loving our enemies. To love one's friends is common practice, to love one's enemies only among Christians.”

Conclusion

The philosophy of love is a field of social philosophy and ethics that attempts to explain the nature of love. The philosophical investigation of love includes the tasks of distinguishing between the various kinds of personal love, asking if and how love is or can be justified, asking what the value of love is, and what impact love has on the autonomy of both the lover and the beloved.

Many different theories attempt to explain the nature and function of love.

Explaining love to a hypothetical person who had not himself or herself experienced love or being loved would be very difficult because to such a person love would appear to be quite strange if not outright irrational behaviour.

Among the prevailing types of theories that attempt to account for the existence of love are: 

psychological theories, the vast majority of which consider love to be very healthy behaviour; 

evolutionary theories which hold that love is part of the process of natural selection

spiritual theories which may, for instance consider love to be a gift from a god;

and theories that consider love to be an unexplainable mystery, very much like a mystical experience.

There were many attempts to find the equation of love. One such attempt was by Christian Rudder, a mathematician and co-founder of online dating website OKCupid, one of the largest online dating sites.

Rudder updated the "OkTrends" blog, which consists of "original research and insights from OkCupid," for the first time in three years in July 2014. Entitled "We Experiment On Human Beings!" the post discusses three experiments run by the website without the knowledge of users. 

Rudder prefaces the experiment results by stating: "... if you use the Internet, you’re the subject of hundreds of experiments at any given time, on every site. That’s how websites work."

Aggregately, dating resources indicate a nascent line of variables effectively synchronising couples in naturally determined yearning.






Tuesday 23 August 2016

Cannabinoids and THC (tetrahydrocannabinol)




Cannabinoids and THC (tetrahydrocannabinol)


Stes de Necker




What is a Cannabinoid

There are over 480 natural components found within the Cannabis sativa plant, of which 66 have been classified as "cannabinoids;" chemicals unique to the plant. The most well known and researched of these, delta-9-tetrahydrocannabinol (Δ9-THC), is the substance primarily responsible for the psychoactive effects of cannabis.

The effects of THC are believed to be moderated by the influence of the other components of the plant, most particularly the cannabinoids.

The cannabinoids are separated into subclasses. These are as follows:
Cannabigerols (CBG);
Cannabichromenes (CBC);
Cannabidiols (CBD);
Tetrahydrocannabinols (THC);
Cannabinol (CBN) and cannabinodiol (CBDL);

Other cannabinoids (such as cannabicyclol (CBL), cannabielsoin (CBE), cannabitriol (CBT) and other miscellaneous types).

What Do Cannabinoids Do

Like opiates (substances derived from the opium poppy such as heroin), cannabinoids affect the user by interacting with specific receptors, located within different parts of the central nervous system. Two kinds of cannabinoid receptors have been found to date and are termed CB1 and CB2. A substance that occurs naturally within the brain and binds to CB1 receptors was discovered in 1992 and termed "anandamide." Additional naturally occurring substances that bind to CB1 have since been discovered, and these, together with the receptors are termed the "endogenous cannabinoid system."

The actual effects that the cannabinoids have reflect the areas of the brain they interact with. Interactions tend to occur in our limbic system (the part of the brain that affects memory, cognition and psychomotor performance) and mesolimbic pathway (activity in this region is associated with feelings of reward) and are also widely distributed in areas of pain perception.

We are still learning about the endogenous cannabinoid system. Much of the research however, has focused on the many potential medical uses of man-made cannabinoids, called "synthetic analogues."

What are the Differences Between Cannabinoids

The major differences between the cannabinoids are determined by the extent to which they are psychologically active. Three classes of cannabinoids, the CBG, CBC and CBD are not known to have such an effect. THC, CBN, CBDL and some other cannabinoids on the other hand are known to be psychologically active to varying degrees.

CBD is probably the most abundant cannabinoid, contributing up to 40% of cannabis resin. Interestingly, CBD may actually have anti-anxiety effects and lessen the psychoactive effects of THC. This means that a plant with a greater percentage of CBD may reduce the intensity of the effects of the THC, which in effect lowers the potency of the plant. Use of a cannabis plant with less CBD has been shown to have an increased psychological impact and result in unwanted effects such as anxiety.

When THC is exposed to air it oxidizes and forms CBN. CBN is only very weakly psychoactive and not unlike CBD interacts with THC to reduce its effects. This is why cannabis that has been left out unused will have increasing amounts of CBN and decreasing amounts of THC and thus lose potency.

THC’s Psychoactive Properties Protect the Brain

Many testing methodologies for cannabis are now significant due to the amount of fake and toxic weed on the market. More agencies are responsible for knowing how safe cannabis is when used for our health purposes. The answer is “very safe” as long as it’s pure. The experience of recreational users gives us some information, but we must understand safety issues in patients who have diseases like high blood pressure or diabetes so they can safely consume cannabis without impurities tainting a therapeutic approach that is far more effective than any drug in existence.

Drug companies are now routinely grinding up pure Cannabis Sativa and creating synthetic versions of delta-9-tetrahydrocannabinol or synthetic ajulemic acid (AjA) and combining it with gelatin, glycerin, iron colored oxides, titanium dioxide and marketing this drugs to doctors and hospitals under the name marinol. However, it doesn’t seem to interact with brain cells in the same way as the plant form, and although it generates no “high”, the molecular mimic of THC does not appear to be as effective as the real thing.

Although the medical benefits of cannabis are suppressed by the pharmaceutical industry that fears its powerful therapeutic properties, this hasn’t stopped users of medical cannabis from relieving chronic ailments, including cancer and post-traumatic stress disorder, to combat pain, insomnia, lack of appetite, and other symptoms. The proven benefits of cannabis clearly indicate it is one of the most significant healing plants on Earth.

THC’s Psychoactive Properties Prevent Brain Damage From Other Toxic Drugs

In contradiction to consistent claims by mainstream science that Cannabis causes brain damage, a 2014 study shows the opposite. Research published in the journals Behavioural Brain Research and Experimental Brain Research demonstrated that even extremely low doses of THC (cannabis’ psychoactive component) — around 1,000 to 10,000 times less than that in a conventional cannabis cigarette — can jumpstart biochemical processes which protect brain cells and preserve cognitive function.

In fact, low doses of THC protect the brain both before and after injury, say researchers from Tel Aviv University (TAU).

Dozens of studies have made pseudoscientific attempts to indicate that young people who use cannabis tend to experience psychological problems, mental decline, neurological damage and even schizophrenia. However, there is no evidence that cannabis use is directly linked with such problems, according to a previous study published in The Lancet and cannabis has been.

Prof. Yosef Sarne of Tel Aviv University’s Adelson Center for the Biology of Addictive Diseases at the Sackler Faculty of Medicine says that the drug has neuroprotective qualities as well. He has found that extremely low doses of THC — the psychoactive component of cannabis — protects the brain from long-term cognitive damage in the wake of injury from hypoxia (lack of oxygen), seizures, or toxic drugs. Brain damage can have consequences ranging from mild cognitive deficits to severe neurological damage.

Previous studies focused on injecting high doses of THC within a very short time frame — approximately 30 minutes — before or after injury. Prof. Sarne’s current research, published in the journals Behavioural Brain Research and Experimental Brain Research, demonstrates that even extremely low doses of THC — around 1,000 to 10,000 times less than that in a conventional cannabis cigarette — administered over a wide window of 1 to 7 days before or 1 to 3 days after injury can jumpstart biochemical processes which protect brain cells and preserve cognitive function over time.

Purity is Essential

Cannabinoids from pure sources can prevent cancer, reduce heart attacks by 66% and insulin dependent diabetes by 58%. Cannabis clinician Dr. William Courtney recommends drinking 4 – 8 ounces of raw flower and leaf juice from any Hemp plant, 5 mg of Cannabidiol (CBD) per kg of body weight, a salad of Hemp seed sprouts and 50 mg of THC taken in 5 daily doses.
Why raw? Heat destroys certain enzymes and nutrients in plants. Incorporating raw cannabis allows for a greater availability of those elements. Those who require large amounts of cannabinoids without the psychoactive effects need to look no further than raw cannabis. In this capacity, it can be used at 60 times more tolerance than if it were heated.


As more research continues on the effectiveness of THC from pure sources especially in low doses, more scientists are discovering the therapeutic powerhouse that Cannabis provides.






The Endocannabinoid System A brief molecular overview




The Endocannabinoid System

A brief molecular overview


Stes de Necker




Cannabis, once a taboo subject, has made a pragmatic shift into mainstream culture. The plant has become a popular topic of conversation worldwide, in part due to changes in public opinion, increased medical access for patients, and a changing approach to drug enforcement focusing on harm reduction rather than criminalization.

Currently, cannabis is the most consumed illicit drug in Western culture (Radhakrishnan et al., 2014), and it has a long history of human use for medicinal purposes (Mechoulam and Parker, 2013).
 However, a turbulent past and restrictive policy have made it difficult to explore the therapeutic mechanisms of cannabis (Pacher et al., 2006).

Despite these major barriers to academic research, our understanding of the molecular mechanisms that mediate the effects of cannabis continues to advance, with the hope that this work may contribute to novel therapies to combat human disease.  The goal of this article is to provide a generalized overview of the intracellular signalling mechanisms that are responsible for the effects of cannabis.

The molecular components of the endocannabinoid system

Originally, it was proposed that the effects of cannabis were mediated by a nonspecific membrane-associated mechanism (Mechoulam and Parker, 2013); however, this hypothesis was later refuted as various components of the endocannabinoid system (ECS) were discovered in the late 1980s and early 90s, revolutionizing our understanding of the effects of cannabis (Howlett et al., 2002).
The ECS is an important and highly conserved cellular signaling pathway found within vertebrates, where it modulates multiple critical physiological processes (Pacher et al., 2006; Russo, 2016). 
Dysregulation of the ECS pathway has been implicated in several human diseases (Mackie, 2006; Pacher et al., 2006).

The ECS is comprised of two cannabinoid receptors (CB), CB1 and CB2, which belong to the G-coupled protein receptor super family, whose members influence various cellular processes by sensing extracellular signalling molecules (Mechoulam and Parker, 2013).  CB1 is most abundantly expressed in the central and peripheral nervous system, with the exception of the brain stem region (Hu and Mackie, 2015).  CB1 is also present, although less abundant, in peripheral organs such as the digestive tract, epidermis, adipose tissue, and skeletal muscle, as well as the cardiovascular, lymphatic, and respiratory systems (Mackie, 2006).  CB2 receptor expression, on the other hand, is mainly restricted to immune cells and tissues, but has recently been described in certain glial and neuronal cell subpopulations, as well as in bone and liver (Mackie, 2006).

CB receptors are endogenously activated by lipid-based ligands, collectively termed the endocannabinoids (listed in Table 1), which bind to CB1 and CB2 with differing affinities and potency (De Petrocellis et al., 2004).  Unlike most other neurotransmitters, which are stored in synaptic vesicles and released upon appropriate cellular stimuli, endocannabinoids are made on demand by postsynaptic neurons and cross the synapse to inhibit presynaptic activity (Mechoulam and Parker, 2013).  Endocannabinoids are also subject to regulation at these synapses.  For example, endocannabinoids are regulated by a known set of enzymes that control ECS activation by modulating ligand levels in response to cellular demand.

Phytocannabinoids

In addition to the endocannabinoids, exogenous plant derived phytocannabinoids also activate the ECS pathway via CB binding (see Table 1).  Polypharmaceutical cannabis produces hundreds of metabolites, including terpenes, flavonoids, phenolic compounds and various cannabinoids (Russo, 2011).  Most notable are the two major cannabinoids found in cannabis: psychoactive ∆-9-tetrahydrocannabinol (THC) and non-psychoactive cannabidiol (CBD).  THC is a partial CB1 and CB2 activator, while CBD has little affinity for CB1 and CB2 but can inhibit THC-receptor binding at low concentrations (Russo and Guy, 2006).

In addition to THC and CBD, other less abundant phytocannabinoids can bind the CB receptors with differing affinities, stimulating or inhibiting downstream ECS activation.   Moreover, terpenoids and other cannabis metabolites are thought to synergistically contribute to the therapeutic effects of phytocannabinoids in a phenomenon known as the ‘entourage effect’ (Russo, 2011).  The entourage effect hypothesis, originally coined by R. Mechoulam’s group (Ben-Shabat et al., 1998), states that complex, multiple compound mixtures show synergistic biological activity, where isolated compounds fail to achieve similar effects, thus providing the rationale for whole plant extracts versus individual compounds in treating disease.

Downstream ECS signalling mechanisms

What do we know about the downstream ECS signalling events?  CB receptors activate a number of signal transduction pathways through the Gi/o family of G-coupled protein receptors in response to extracellular ligand binding, which in turn influence key cellular processes (Howlett et al., 2002) 

For example, ECS activation influences several types of ion channels and it is hypothesized that short, versus sustained, CB activation may underlie differences in downstream intracellular signalling, where pathway stimulation for seconds alters ion channels and sustained activation modulates intracellular enzymes activity, such as protein kinase A (PKA) and Mitogen-activated protein kinase (MAPK) (Stella, 2009).

As well, the ECS pathway is implicated in regulating immediate early gene family expression, protein synthesis and nitric oxide production (Howlett et al., 2002).  In cancer and tumour cells, elevated ceramide release by a CB-dependent mechanism has been linked to decreased cellular growth and increased programmed cell death within these cells (Howlett et al., 2002).

Thus, ECS activation appears to influence a number of key, context dependent cellular signaling mechanisms, and the future challenge will be to understand exactly how these ECS-dependent signaling events translate into physiological changes at the tissue level.  We do know, for example, that CB1 activation in the central nervous system suppresses neurotransmitter release at excitatory and inhibitory synapses (Mechoulam and Parker, 2013), and CB2 activation modulates immune system function by inhibiting cytokine release and immune cell migration (Mechoulam and Parker, 2013), which is thought to contribute to the therapeutic benefits reported by patients.

Other signalling pathways influenced by Endocannabinoids

CB receptors have an affinity for endocannabinoids, phytocannabinoids and a number of synthetic compounds that often activate or block one type of receptor more potently than another, but are there non-CB receptor targets for these ligands?  If so, what is the physiological consequence of binding these alternative receptors, and does this mechanism contribute to any disease conditions or therapeutic application of phytocannabinoids?

It is known that canonical ECS ligands, such as endocannabinoids and phytocannabinoids, can influence other major cell signalling pathways.  For example, CBD modulates serotonin signalling (Franklin and Carrasco, 2014; Resstel et al., 2009; Russo et al., 2005), an important chemical messenger in the regulation of emotional state, pain, and behaviour, and this mechanism has been linked to CBD-dependent anxiolytic-like effects (Resstel et al., 2009).

Also, Vanilloid type 1 receptor (TRPV1), a putative cannabinoid receptor, is activated by several endocannabinoids (Pertwee, 2006) and is implicated in the regulation of vasodilation, thermoregulation and pain (Elphick and Egertova, 2001).  Similarly, GPR55, another hypothesized putative cannabinoid receptor, is activated by canonical ECS ligands. And although the exact physiological significance of GPR55 activation is unknown (Brown, 2007), it has been implicated in the regulation of bone development (Whyte et al., 2009), cancer cell proliferation (Pineiro et al., 2011), and inflammation (Balenga et al., 2011).  Evidence also suggests endocannabinoids and phytocannabinoids activate the peroxisome proliferators-activated receptor (PPAR) family, which primarily regulates energy balance and metabolism, cell differentiation and inflammation (O’Sullivan, 2007).

More recently, phtyocannabinoids and endocannabinoids were shown to inhibit the Hedgehog pathway, a signalling system critically important during development and tissue homeostasis, by direct receptor inhibition (Khaliullina et al., 2015).

Taken together, the promiscuity of typical ECS ligands to bind and activate other pathways raises the interesting possibility that some of the effects of cannabis could be a result of ECS-independent signalling, widening the scope of mechanistic investigation beyond simply CB1 and CB2 receptors.

Conclusion

Our understanding of the ECS system and the use of cannabis as a therapeutic tool in pathological and normal conditions is becoming more clear, but there remain significant gaps in our understanding of these processes.  The next major challenge, from a research perspective, will be tying together how downstream intracellular signalling mechanisms influence tissue and organ system function, and how these changes can be exploited to treat human disease.  Currently, access to cannabis for research purposes is cumbersome.  As laws change, it will be increasingly important that policy be updated to better balance the restriction of access to reduce public harm with the need for reasonable access to the plant for research purposes.

Increasing access to cannabis for research by reducing hurdles and maintaining a rational approach to drug policy will allow Canada to become an international leader in the field of cannabis research. This in turn will lead to large economic benefits, in the form of improved or novel therapeutic treatments to combat human disease, and and new or improved agricultural markets.
Table 1. List of Endocannabinoids and major phytocannabinoids.

Endocanabinoids
2-arachidonoyl glycerol (2-AG)
N-arachidonoyl-ethanolamine (anandamide, AEA)
2-arachidonyl-glyeryl ether (Noladin, 2-AGE)
O-arachidonyl-thanolamine (virhodamine)
N-arachidonoyl-dopamine (NADA)

Phytocannabinoids
Cannabigerol (CBG)
∆-9-tetrahydrocannabinol (THC)
Cannabidiol (CBD)
Cannabichromene (CBC)
Cannabinol (CBN)

-Dr. Charles Campbell and Dr. Randy Ringuette

Dr. Charles Campbell and Dr. Randy Ringuette are experienced life scientists who share a strong passion for improving the healthcare system and treatment of human disease through basic research.
Together,they have over 15 years in a medical research environment and have published multiple original, peer-reviewed publications.
Both Dr. Campbell and Dr. Ringuette hold a Ph.D. degree in Cellular & Molecular Medicine and an honours B.Sc. degree in Biology from the University of Ottawa, and they are joint founders of Apical Science Inc., a scientific consulting and research group focused on the emerging Canadian Cannabis Industry.

Citations

Balenga, N. A., Aflaki, E., Kargl, J., Platzer, W., Schroder, R., Blattermann, S., Kostenis, E., Brown, A. J., Heinemann, A., Waldhoer, M., 2011. GPR55 regulates cannabinoid 2 receptor-mediated responses in human neutrophils. Cell Res. 21, 1452-69.
Ben-Shabat, S., Fride, E., Sheskin, T., Tamiri, T., Rhee, M. H., Vogel, Z., Bisogno, T., De Petrocellis, L., Di Marzo, V., Mechoulam, R., 1998. An entourage effect: inactive endogenous fatty acid glycerol esters enhance 2-arachidonoyl-glycerol cannabinoid activity. Eur J Pharmacol. 353, 23-31.
Brown, A. J., 2007. Novel cannabinoid receptors. Br J Pharmacol. 152, 567-75.
De Petrocellis, L., Cascio, M. G., Di Marzo, V., 2004. The endocannabinoid system: a general view and latest additions. Br J Pharmacol. 141, 765-74.
Elphick, M. R., Egertova, M., 2001. The neurobiology and evolution of cannabinoid signalling. Philos Trans R Soc Lond B Biol Sci. 356, 381-408.
Franklin, J. M., Carrasco, G. A., 2014. Cannabinoid receptor agonists upregulate and enhance serotonin 2A (5-HT(2A)) receptor activity via ERK1/2 signaling. Synapse. 67, 145-59.
Howlett, A. C., Barth, F., Bonner, T. I., Cabral, G., Casellas, P., Devane, W. A., Felder, C. C., Herkenham, M., Mackie, K., Martin, B. R., Mechoulam, R., Pertwee, R. G., 2002. International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacol Rev. 54, 161-202.
Hu, S. S., Mackie, K., 2015. Distribution of the Endocannabinoid System in the Central Nervous System. Handb Exp Pharmacol. 231, 59-93.
Khaliullina, H., Bilgin, M., Sampaio, J. L., Shevchenko, A., Eaton, S., 2015. Endocannabinoids are conserved inhibitors of the Hedgehog pathway. Proc Natl Acad Sci U S A. 112, 3415-20.
Mackie, K., 2006. Cannabinoid receptors as therapeutic targets. Annu Rev Pharmacol Toxicol. 46, 101-22.
Mechoulam, R., Parker, L. A., 2013. The endocannabinoid system and the brain. Annu Rev Psychol. 64, 21-47.
O’Sullivan, S. E., 2007. Cannabinoids go nuclear: evidence for activation of peroxisome proliferator-activated receptors. Br J Pharmacol. 152, 576-82.
Pacher, P., Batkai, S., Kunos, G., 2006. The endocannabinoid system as an emerging target of pharmacotherapy. Pharmacol Rev. 58, 389-462.
Pertwee, R. G., 2006. The pharmacology of cannabinoid receptors and their ligands: an overview. Int J Obes (Lond). 30 Suppl 1, S13-8.
Pineiro, R., Maffucci, T., Falasca, M., 2011. The putative cannabinoid receptor GPR55 defines a novel autocrine loop in cancer cell proliferation. Oncogene. 30, 142-52.
Radhakrishnan, R., Wilkinson, S. T., D’Souza, D. C., 2014. Gone to Pot – A Review of the Association between Cannabis and Psychosis. Front Psychiatry. 5, 54.
Resstel, L. B., Tavares, R. F., Lisboa, S. F., Joca, S. R., Correa, F. M., Guimaraes, F. S., 2009. 5-HT1A receptors are involved in the cannabidiol-induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats. Br J Pharmacol. 156, 181-8.
Russo, E., Guy, G. W., 2006. A tale of two cannabinoids: the therapeutic rationale for combining tetrahydrocannabinol and cannabidiol. Med Hypotheses. 66, 234-46.
Russo, E. B., 2011. Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects. Br J Pharmacol. 163, 1344-64.
Russo, E. B., 2016. Beyond Cannabis: Plants and the Endocannabinoid System. Trends Pharmacol Sci.
Russo, E. B., Burnett, A., Hall, B., Parker, K. K., 2005. Agonistic properties of cannabidiol at 5-HT1a receptors. Neurochem Res. 30, 1037-43.
Stella, N., 2009. Endocannabinoid signaling in microglial cells. Neuropharmacology. 56 Suppl 1, 244-53.
Whyte, L. S., Ryberg, E., Sims, N. A., Ridge, S. A., Mackie, K., Greasley, P. J., Ross, R. A., Rogers, M. J., 2009. The putative cannabinoid receptor GPR55 affects osteoclast function in vitro and bone mass in vivo. Proc Natl Acad Sci U S A. 106, 16511-6.


Monday 22 August 2016

Medical Marijuana and Cannabis studies A collection of clinical studies, papers and reference providing the ultimate resource for medical disorders helped by medical marijuana.




Medical Marijuana and Cannabis studies 

A collection of clinical studies, papers and reference providing the ultimate resource for medical disorders helped by medical marijuana.



Stes de Necker





ADD/ ADHD

Marijuana and ADD Therapeutic uses of Medical Marijuana in the treatment of ADD
http://www.onlinepot.org/medical/add&mmj.htm

Cannabis as a medical treatment for attention deficit disorder
http://www.chanvre-info.ch/info/en/...-treatment.html

Cannabinoids effective in animal model of hyperactivity disorder
http://www.cannabis-med.org/english...el.php?id=162#4

Cannabis 'Scrips to Calm Kids?
http://www.foxnews.com/story/0,2933,117541,00.html

Addiction risk- Physical

Women's Guide to the UofC
http://wguide.uchicago.edu/9substance.html

Cannabis Basics
http://www.erowid.org/plants/cannab...is_basics.shtml

10 Things Every Parent, Teenager & Teacher Should Know About Marijuana (4th Q)
http://www.erowid.org/plants/cannab...is_flyer1.shtml

Marijuana Myths, Claim No. 9http://www.erowid.org/plants/cannab...bis_myth9.shtml

AIDS – see HIV

Alcoholism

Role of cannabinoid receptors in alcohol abuse
http://www.medicalnewstoday.com/articles/30338.php

Cannabidiol, Antioxidants, and Diuretics in Reversing Binge Ethanol-Induced Neurotoxicity
http://jpet.aspetjournals.org/cgi/c...ourcetype=HWCIT

Cannabis substitution
http://www.cannabis-med.org/studies...how.php?s_id=86

Cannabis as a Substitute for Alcohol
http://ccrmg.org/journal/03sum/substitutealcohol.html

ALS

Cannabinol delays symptom onset
http://www.ncbi.nlm.nih.gov/sites/e...t_uids=16183560

Marijuana in the management of amyotrophic lateral sclerosis
http://www.medscape.com/medline/abstract/11467101

Cannabis use in patients with amyotrophic lateral sclerosis.
http://www.medscape.com/medline/abstract/15055508

Cannabis Relieves Lou Gehrigs Symptoms
http://www.rense.com/general51/lou.htm

Cannabis' Potential Exciting Researchers in Treatment of ALS, Parkinson's Disease
http://66.218.69.11/search/cache?ei...&icp=1&.intl=us

Alzheimers

MARIJUANA SLOWS ALZHEIMER'S DECLINE
http://www.mapinc.org/drugnews/v05/n307/a10.html

Marijuana may block Alzheimer's
http://news.bbc.co.uk/2/hi/health/4286435.stm

Prevention of Alzheimer's Disease Pathology by Cannabinoids
http://www.jneurosci.org/cgi/content/abstract/25/8/1904

Marijuana's Active Ingredient Shown to Inhibit Primary Marker of Alzheimer's Disease
http://www.pacifier.com/~alive/articles/ca060809.htm

Dronabinol in the treatment of agitation in patients with Alzheimer’s disease with anorexia
http://www.cannabis-med.org/studies...how.php?s_id=61

Dronabinol in the treatment of refractory agitation in Alzheimer’s disease
http://www.cannabis-med.org/studies...how.php?s_id=92

Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimer's disease.
http://www.cannabis-med.org/studies...how.php?s_id=59

Cannabinoids reduce the progression of Alzheimer's disease in animals
http://www.cannabis-med.org/english...el.php?id=187#1
Molecular Link between the Active Component of Marijuana and Alzheimer's Disease Pathology
http://www.unboundmedicine.com/medl...sease_Pathology

THC inhibits primary marker of Alzheimer's disease
http://www.cannabis-med.org/english...el.php?id=225#3

Amotivational Syndrome

Amotivational Syndrome
http://leda.lycaeum.org/?ID=12454

Marijuana Myths, Claim No. 11
http://www.erowid.org/plants/cannab...is_myth11.shtml

Debunking 'Amotivational Syndrome'
http://www.mapinc.org/drugnews/v06/n400/a06.html

Amotivational Syndrome
http://www.bookrags.com/Amotivational_syndrome

Debunking the Amotivational Syndrome
http://www.drugscience.org/Petition/C3F.html

Cannabis Use Not Linked To So-Called "Amotivational Syndrome"
http://www.norml.org/index.cfm?Grou...tm_format=print

Anecdotal Evidence/First person stories

Appetite Stimulant

Dronabinol an effective appetite stimulant?
http://www.cannabis-med.org/studies...ow.php?s_id=188

THC improves appetite and reverses weight loss in AIDS patients
http://www.cannabis-med.org/studies...ow.php?s_id=189

Efficacy of dronabinol alone and in combination
http://www.cannabis-med.org/studies...ow.php?s_id=191

Dronabinol and marijuana in HIV-positive marijuana smokers: caloric intake, mood, and sleep.
http://www.cannabis-med.org/studies...ow.php?s_id=190

The synthetic cannabinoid nabilone improves pain and symptom management in cancer patients
http://www.cannabis-med.org/studies...ow.php?s_id=177

Dronabinol for supportive therapy in patients with malignant melanoma and liver metastases
http://www.cannabis-med.org/studies...ow.php?s_id=180

Safety and efficacy of dronabinol in the treatment of agitation in patients with Alzheimer’s disease
http://www.cannabis-med.org/studies...how.php?s_id=61

The perceived effects of smoked cannabis on patients with multiple sclerosis.
http://www.cannabis-med.org/studies...how.php?s_id=13

Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimer's disease
http://www.cannabis-med.org/studies...how.php?s_id=59

Dronabinol as a treatment for anorexia associated with weight loss in patients with AIDS.
http://www.cannabis-med.org/studies...how.php?s_id=21

Delta-9-tetrahydrocannabinol for appetite stimulation in cancer-associated anorexia
http://www.cannabis-med.org/studies...how.php?s_id=52

Effect of dronabinol on nutritional status in HIV infection.
http://www.cannabis-med.org/studies...ow.php?s_id=150

Dronabinol stimulates appetite and causes weight gain in HIV patients.
http://www.cannabis-med.org/studies...how.php?s_id=20

Dronabinol effects on weight in patients with HIV infection.
http://www.cannabis-med.org/studies...how.php?s_id=45

Recent clinical experience with dronabinol.
http://www.cannabis-med.org/studies...how.php?s_id=90
Dronabinol enhancement of appetite in cancer patients.
http://www.cannabis-med.org/studies...ow.php?s_id=149

Effects of smoked marijuana on food intake and body weight
http://www.cannabis-med.org/studies...ow.php?s_id=117

Behavioral analysis of marijuana effects on food intake in humans.
http://www.cannabis-med.org/studies...ow.php?s_id=118

Cancer-related anorexia-cachexia syndrome
http://www.unboundmedicine.com/medl...xia_Study_Group

THC effective in appetite and weight loss in severe lung disease (COPD)
http://www.cannabis-med.org/english...el.php?id=191#2

Machinery Of The 'Marijuana Munchies'
http://www.sciencedaily.com/release...51226102503.htm

Arthritis

Cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis
http://www.pnas.org/cgi/content/full/97/17/9561

The Cannabinergic System as a Target for Anti-inflammatory Therapies
http://www.ingentaconnect.com/conte...000013/art00008

Sativex in the treatment of pain caused by rheumatoid arthritis
http://rheumatology.oxfordjournals....bstract/45/1/50

Suppression of fibroblast metalloproteinases by ajulemic acid,
http://ccicnewsletter.com/index.php...06_Rheumatology

The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat
http://www.unboundmedicine.com/medl...binoid_receptor

Synergy between Delta(9)-tetrahydrocannabinol and morphine in the arthritic rat
http://www.unboundmedicine.com/medl...e_arthritic_rat

Cannabis based medicine eases pain and suppresses disease
http://www.medicalnewstoday.com/articles/33376.php

Pot-Based Drug Promising for Arthritis
http://www.webmd.com/rheumatoid-art...g-for-arthritis

Asthma

The Cannabinergic System as a Target for Anti-inflammatory Therapies
http://www.ingentaconnect.com/conte...000013/art00008

Acute and subacute bronchial effects of oral cannabinoids.
http://www.cannabis-med.org/studies...how.php?s_id=44

Comparison of bronchial effects of nabilone and terbutaline
http://www.cannabis-med.org/studies...how.php?s_id=43

Bronchial effects of aerosolized delta 9-tetrahydrocannabinol
http://www.cannabis-med.org/studies...ow.php?s_id=109

Bronchodilator effect of delta1-tetrahydrocannabinol administered by aerosol
http://www.cannabis-med.org/studies...how.php?s_id=60

Effects of smoked marijuana in experimentally induced asthma.
http://www.cannabis-med.org/studies...how.php?s_id=57

Marijuana and oral delta9-tetrahydrocannabinol on specific airway conductance
http://www.cannabis-med.org/studies...how.php?s_id=67

New Synthetic Delta-9-THC Inhaler Offers Safe, Rapid Delivery
http://www.medicalnewstoday.com/articles/22937.php

Smoked marijuana and oral delta-9-THC on specific airway conductance in asthmatic subjects
http://www.ukcia.org/research/Smoke...InAsthmatic.php

Atherosclerosis

Marijuana Chemical Fights Hardened Arteries
http://www.webmd.com/heart-disease/...rdened-arteries

Does Cannabis Hold the Key to Treating Cardiometabolic Disease
http://www.medscape.com/viewarticle/525040_print

Cannabis may keep arteries clear
http://www.gnn.tv/headlines/2634/Ca..._arteries_clear

The Cannabinergic System as a Target for Anti-inflammatory Therapies
http://www.ingentaconnect.com/conte...000013/art00008

Cannabis compound tackles blood vessel disease
http://www.medicalnewstoday.com/articles/22658.php

Medical marijuana: study shows that THC slows atherosclerosis
http://thenexthurrah.typepad.com/th...al_marijua.html

Cardiovascular Effects of Cannabis
http://www.idmu.co.uk/canncardio.htm

Atrophie Blanche

Atrophie Blanche Treated With Cannabis and/or THC
http://ccrmg.org/journal/04spr/clinical.html#thm

Autism

Autism and Medical Marijuana
http://www.autism.org/marijuana.html

THE SAM PROJECT: James D.
http://www.letfreedomgrow.com/articles/james_d.htm

Medical marijuana: a valuable treatment for autism?
http://www.autismwebsite.com/ari/ne...r/marijuana.htm

Cancer – breast

Anandamide inhibits human breast cancer cell proliferation
http://www.pnas.org/cgi/content/abstract/95/14/8375

Inhibition of Human Breast and Prostate Cancer Cell Proliferation1
http://endo.endojournals.org/cgi/co...tract/141/1/118

Antitumor Activity of Plant Cannabinoids
http://jpet.aspetjournals.org/cgi/c...ract/318/3/1375

9-Tetrahydrocannabinol Inhibits Cell Cycle Progression in Human Breast Cancer
http://cancerres.aacrjournals.org/c...ract/66/13/6615

Cannabidiol inhibits tumour growth in leukaemia and breast cancer
http://www.cannabis-med.org/english...el.php?id=220#2

THC and prochlorperazine effective in reducing vomiting in women following breast surgery
http://www.cannabis-med.org/english...el.php?id=219#1

Cancer- colorectal

Anandamide, induces cell death in colorectal carcinoma cells
http://gut.bmj.com/cgi/content/abstract/54/12/1741

Cannabinoids and cancer: potential for colorectal cancer therapy.
http://www.medscape.com/medline/abstract/16042581

Cancer- glioma/ brain

Anti-tumor effects of cannabidiol
http://www.hempworld.com/HempPharm/...milanstudy.html

Pot’s cancer healing properties
http://www.november.org/stayinfo/br...ncerKiller.html

Cannabinoids Inhibit the Vascular Endothelial Growth Factor Pathway in Gliomas
http://cancerres.aacrjournals.org/c...hort/64/16/5617

Inhibition of Glioma Growth in Vivo
http://cancerres.aacrjournals.org/c.../61/15/5784.pdf

Delta(9)-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme.
http://www.cannabis-med.org/studies...ow.php?s_id=193

Cannabidiol triggers caspase activation and oxidative stress in human glioma cells.
http://www.ihop-net.org/UniPub/iHOP...l?pmid=16909207

Cannabinoid receptors in human astroglial tumors
http://www.brainlife.org/abstracts/...t_j20060800.pdf

Cannabis extract makes brain tumors shrink, halts growth of blood vessels
http://www.medicalnewstoday.com/articles/12088.php

THC tested against brain tumour in pilot clinical study
http://www.cannabis-med.org/english...el.php?id=222#1

Cancer- leukemia

Cannabis-induced cytotoxicity in leukemic cell lines
http://bloodjournal.hematologylibra...ract/105/3/1214

Cannabidiol-Induced Apoptosis in Human Leukemia Cells
http://molpharm.aspetjournals.org/c...stract/70/3/897

Marijuana's Active Ingredient Kills Leukemia Cells
http://www.treatingyourself.com/vbu...read.php?t=7107

Targeting CB2 cannabinoid receptors to treat malignant lymphoblastic disease
http://bloodjournal.hematologylibra...t/100/2/627.pdf

Cannabinoids induce incomplete maturation of cultured human leukemia cells
http://www.osti.gov/energycitations...osti_id=5164483

{Delta}9-Tetrahydrocannabinol-Induced Apoptosis in Jurkat Leukemia T Cells
http://mcr.aacrjournals.org/cgi/con...bstract/4/8/549

Cannabidiol inhibits tumour growth in leukaemia and breast cancer
http://www.cannabis-med.org/english...el.php?id=220#2

Cancer- lung

Antineoplastic activity of cannabinoids
http://www.ukcia.org/research/Antin...ds/default.html

Delta(9)-Tetrahydrocannabinol inhibits epithelial growth factor-induced lung cancer cell migration
http://www.unboundmedicine.com/medl...astasis_in_vivo

Smoking Cannabis Does Not Cause Cancer Of Lung or Upper Airways
http://ccrmg.org/journal/05aut/nocancer.html

No association between lung cancer and cannabis smoking in large study
http://www.cannabis-med.org/english...el.php?id=219#2

Marijuana Smoking Found Non-Carcinogenic
http://www.medpagetoday.com/Hematol...gCancer/tb/3393

CLAIM #4: MARIJUANA CAUSES LUNG DISEASE
http://www.erowid.org/plants/cannab...bis_myth4.shtml

Cancer- melanoma

Dronabinol for supportive therapy in patients with malignant melanoma and liver metastases.
http://www.cannabis-med.org/studies...ow.php?s_id=180

Intractable nausea and vomiting due to gastrointestinal mucosal metastases
http://www.cannabis-med.org/studies...how.php?s_id=35

Cancer – oral
Smoking of cannabis does not increase risk for oral cancer
http://www.cannabis-med.org/english...el.php?id=175#1

Marijuana use and Risk of Oral Squamous Cell Carcinoma
http://66.218.69.11/search/cache?ei...&icp=1&.intl=us

Cancer-pancreatic

Cannabinoids Induce Apoptosis of Pancreatic Tumor Cells
http://cancerres.aacrjournals.org/c...ract/66/13/6748

Cancer – prostate

Inhibition of Human Breast and Prostate Cancer Cell Proliferation
http://endo.endojournals.org/cgi/co...tract/141/1/118

Cannabinoid Receptor as a Novel Target for the Treatment of Prostate Cancer
http://cancerres.aacrjournals.org/c...t/65/5/1635.pdf

Cancer – Risk Cannabis vs Tobacco

Cannabis Smoke and Cancer: Assessing the Risk
http://www.norml.org/index.cfm?Group_ID=6891

Cannabis and tobacco smoke are not equally carcinogenic
http://www.pubmedcentral.nih.gov/ar...i?artid=1277837

Smoking Marijuana Does Not Cause Lung Cancer
http://www.mapinc.org/drugnews/v05/n1065/a03.html

Blunt Smokers Link Dependence Potential To Nicotine
http://www.medicalnewstoday.com/articles/52838.php

Premiere British Medical Journal Pronounces Marijuana Safer Than Alcohol, Tobacco
http://cannabislink.ca/medical/safer.html

Why Doesn't Smoking Marijuana Cause Cancer?
http://www.healthcentral.com/drdean/408/14275.html

Marijuana Smoking Found Non-Carcinogenic
http://www.medpagetoday.com/Hematol...gCancer/tb/3393

Cancer – Skin

Inhibition of skin tumor growth
http://www.jci.org/cgi/content/full...y=MpUgjDbqHybAU

Cannabis Reduces Skin Cancer
http://www.onlinepot.org/medical/skincancerreport.htm

Cancer – Testicular

The antiemetic efficacy of nabilone
http://www.cannabis-med.org/studies...ow.php?s_id=127

Chemotherapy for Testicular Cancer
http://www.rxmarihuana.com/shared_c...icularchemo.htm

Cancer –various/ unnamed

Nabilone improves pain and symptom management
http://www.cannabis-med.org/studies...ow.php?s_id=177

The effects of smoked cannabis in painful peripheral neuropathy
http://www.cannabis-med.org/studies...how.php?s_id=96

Delta-9-tetrahydrocannabinol for appetite stimulation
http://www.cannabis-med.org/studies...how.php?s_id=52

Dronabinol and prochlorperazine in combination
http://www.cannabis-med.org/studies...how.php?s_id=28

Dronabinol enhancement of appetite in cancer patients.
http://www.cannabis-med.org/studies...ow.php?s_id=149

Efficacy of tetrahydrocannabinol
http://www.cannabis-med.org/studies...how.php?s_id=31

Inhalation marijuana as an antiemetic for cancer chemotherapy.
http://www.cannabis-med.org/studies...ow.php?s_id=155
Nabilone versus domperidone
http://www.cannabis-med.org/studies...ow.php?s_id=129

Inhalation marijuana as an antiemetic for cancer chemotherapy.
http://www.cannabis-med.org/studies...ow.php?s_id=155

Nabilone vs. placebo in chemotherapy-induced nausea and vomiting
http://www.cannabis-med.org/studies...ow.php?s_id=156

The antiemetic activity of tetrahydrocanabinol versus metoclopramide
http://www.cannabis-med.org/studies...how.php?s_id=24

Delta-9-tetrahydrocannabinol as an antiemetic for patients receiving cancer chemotherapy
http://www.cannabis-med.org/studies...show.php?s_id=5

Delta-9-tetrahydrocannabinol as an antiemetic in cancer patients receiving high-dose methotrexate
http://www.cannabis-med.org/studies...how.php?s_id=23

Delta-9-tetrahydrocannabinol (THC) as an antiemetic in patients treated with cancer chemotherapy
http://www.cannabis-med.org/studies...how.php?s_id=27

Amelioration of cancer chemotherapy-induced nausea and vomiting by delta-9-THC
http://www.cannabis-med.org/studies...ow.php?s_id=107

Superiority of nabilone over prochlorperazine as an antiemetic
http://www.cannabis-med.org/studies...ow.php?s_id=126

Analgesic effect of delta-9-tetrahydrocannabinol.
http://www.cannabis-med.org/studies...how.php?s_id=16

The analgesic properties of delta-9-tetrahydrocannabinol and codeine.
http://www.cannabis-med.org/studies...how.php?s_id=17

Comparison of orally administered cannabis extract and delta-9-THC
http://www.unboundmedicine.com/medl...xia_Study_Group

Cannabis May Help Combat Cancer-causing Herpes Viruses
http://www.sciencedaily.com/release...40923092627.htm

Marijuana Smoking Found Non-Carcinogenic
http://www.medpagetoday.com/Hematol...gCancer/tb/3393

Cannabidiol

Cannabidiol, Antioxidants, and Diuretics in Reversing Binge Ethanol-Induced Neurotoxicity
http://jpet.aspetjournals.org/cgi/c...ourcetype=HWCIT

Cannabinol delays symptom onset
http://www.ncbi.nlm.nih.gov/sites/e...t_uids=16183560

Cannabidiol is an oral anti-arthritic therapeutic in murine collagen-induced arthritis
http://www.pnas.org/cgi/content/full/97/17/9561

Cannabidiol inhibits tumour growth in leukaemia and breast cancer
http://www.cannabis-med.org/english...el.php?id=220#2

Anti-tumor effects of cannabidiol
http://www.hempworld.com/HempPharm/...milanstudy.html

Cannabidiol triggers caspase activation and oxidative stress in human glioma cells.
http://www.ihop-net.org/UniPub/iHOP...l?pmid=16909207

Cannabidiol-Induced Apoptosis in Human Leukemia Cells
http://molpharm.aspetjournals.org/c...stract/70/3/897

Cannabidiol inhibits tumour growth in leukaemia and breast cancer
http://www.cannabis-med.org/english...el.php?id=220#2

Cannabidiol lowers incidence of diabetes in non-obese diabetic mice
http://www.ingentaconnect.com/conte...sn7o5efqr.alice
Neuroprotective and Blood-Retinal Barrier-Preserving Effects of Cannabidiol
http://ajp.amjpathol.org/cgi/content/full/168/1/235

Evaluation of cannabidiol in dystonic movement disorders
http://www.cannabis-med.org/studies...how.php?s_id=14

Cannabidiol in dystonic movement disorders.
http://www.cannabis-med.org/studies...ow.php?s_id=139

Beneficial and adverse effects of cannabidiol in a Parkinson patient
http://www.cannabis-med.org/studies...ow.php?s_id=142

Treatment of Meige's syndrome with cannabidiol.
http://www.cannabis-med.org/studies...ow.php?s_id=114

CANNABIDIOL TO HEALTHY VOLUNTEERS AND EPILEPTIC PATIENTS
http://web.acsalaska.net/~warmgun/es201.html

Chronic administration of cannabidiol to healthy volunteers and epileptic patients.
http://www.cannabis-med.org/studies...how.php?s_id=42

Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol
http://www.unboundmedicine.com/medl...f_peroxynitrite

EFFECTS OF CANNABIDIOL IN HUNTINGTON'S DISEASE
http://www.druglibrary.org/schaffer...al/hunting1.htm

The therapeutic rationale for combining tetrahydrocannabinol and cannabidiol.
http://www.medscape.com/medline/abstract/16209908

Cannabidiol has a cerebroprotective action
http://www.unboundmedicine.com/medl...iting_mechanism

Cannabidiol as an antipsychotic
http://www.cannabis-med.org/studies...ow.php?s_id=171

Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats.
http://www.medscape.com/medline/abs...844117?prt=true

Who's Afraid of Cannabidiol?
http://www.counterpunch.org/gardner07142007.html

Chemical composition

Cannabis: A source of useful pharma compounds
http://www.medpot.net/forums/index.php?showtopic=18608
Pharmacokinetics and cannabinoid action using oral cannabis extract

http://www.pharma-lexicon.com/medic...hp?newsid=29638

Pharmacokinetics of cannabinoids
http://66.218.69.11/search/cache?ei...&icp=1&.intl=us

The chemistry and biological activity of cannabis
http://www.unodc.org/unodc/en/bulle....html?print=yes

Differential effects of medical marijuana based on strain and route of administration
http://www.medicalmarijuanaprocon.o...trainsstudy.pdf

What is THC?
http://www.medicalmarijuanaprocon.o...1.0373456855945

Cannabis / Marijuana ( ? 9 -Tetrahydrocannabinol, THC)
http://www.nhtsa.dot.gov/people/inj...gs/cannabis.htm

Chemotherapy

Efficacy of dronabinol alone and in combination
http://www.cannabis-med.org/studies...ow.php?s_id=191

Dronabinol for supportive therapy in patients with malignant melanoma and liver metastases
http://www.cannabis-med.org/studies...ow.php?s_id=180

Intractable nausea and vomiting
http://www.cannabis-med.org/studies...how.php?s_id=35

An efficient new cannabinoid antiemetic in pediatric oncology
http://www.cannabis-med.org/studies...show.php?s_id=7

Dronabinol and prochlorperazine in combination
http://www.cannabis-med.org/studies...how.php?s_id=28

Marijuana as antiemetic medicine
http://www.cannabis-med.org/studies...ow.php?s_id=134

Efficacy of tetrahydrocannabinol in patients refractory to standard anti-emetic therapy
http://www.cannabis-med.org/studies...how.php?s_id=31

Inhalation marijuana as an antiemetic for cancer chemotherapy.
http://www.cannabis-med.org/studies...ow.php?s_id=155

Nabilone versus prochlorperazine
http://www.cannabis-med.org/studies...ow.php?s_id=120

Nabilone: an alternative antiemetic for cancer chemotherapy.
http://www.cannabis-med.org/studies...ow.php?s_id=123

Antiemetic efficacy of nabilone and alizapride
http://www.cannabis-med.org/studies...ow.php?s_id=127

Nabilone versus domperidone
http://www.cannabis-med.org/studies...ow.php?s_id=129

THC or Compazine for the cancer chemotherapy patient
http://www.cannabis-med.org/studies...how.php?s_id=34

Comparison of nabilone and prochlorperazine
http://www.cannabis-med.org/studies...ow.php?s_id=128

Nabilone vs. prochlorperazine for refractory emesis
http://www.cannabis-med.org/studies...ow.php?s_id=146

Nabilone vs. placebo
http://www.cannabis-med.org/studies...ow.php?s_id=156

Tetrahydroannabinol (THC) vs prochlorperazine as chemotherapy antiemetics.
http://www.cannabis-med.org/studies...how.php?s_id=30

Comparative trial of the antiemetic effects of THC and haloperidol
http://www.cannabis-med.org/studies...how.php?s_id=64

Comparison of delta-9-tetrahydrocannabinol and prochlorperazine
http://www.cannabis-med.org/studies...show.php?s_id=3

Delta 9-tetrahydrocannabinol in cancer chemotherapy.
http://www.cannabis-med.org/studies...how.php?s_id=88

Antiemetic effect of tetrahydrocannabinol
http://www.cannabis-med.org/studies...show.php?s_id=6

Tetrahydrocanabinol versus metoclopramide and thiethylperazine
http://www.cannabis-med.org/studies...how.php?s_id=24

Effects of nabilone and prochlorperazine on chemotherapy-induced emesis
http://www.cannabis-med.org/studies...ow.php?s_id=131

Delta-9-tetrahydrocannabinol as an antiemetic
http://www.cannabis-med.org/studies...show.php?s_id=5
Delta-9-tetrahydrocannabinol as an antiemetic in cancer patients receiving high-dose methotrexate
http://www.cannabis-med.org/studies...how.php?s_id=23

THC as an antiemetic in patients treated with cancer chemotherapy
http://www.cannabis-med.org/studies...how.php?s_id=27

Amelioration of cancer chemotherapy-induced nausea and vomiting by delta-9-THC
http://www.cannabis-med.org/studies...ow.php?s_id=107

Superiority of nabilone over prochlorperazine
http://www.cannabis-med.org/studies...ow.php?s_id=126

Antiemetic effect of delta-9-tetrahydrocannabinol
http://www.cannabis-med.org/studies...show.php?s_id=4

Children 

Experiences with THC-treatment in children and adolescents
http://www.cannabis-med.org/studies...how.php?s_id=80

An efficient new cannabinoid antiemetic in pediatric oncology.
http://www.cannabis-med.org/studies...show.php?s_id=7

Nabilone versus prochlorperazine for control of cancer chemotherapy-induced emesis in children
http://www.cannabis-med.org/studies...ow.php?s_id=120

Nabilone: an alternative antiemetic for cancer chemotherapy.
http://www.cannabis-med.org/studies...ow.php?s_id=123

Marijuana and ADD Therapeutic uses of Medical Marijuana in the treatment of ADD
http://www.onlinepot.org/medical/add&mmj.htm

Oily fish makes 'babies brainier'
http://news.bbc.co.uk/2/hi/health/4631006.stm

Cannabis is a First-Line Treatment for Childhood Mental Disorders
http://www.counterpunch.org/mikuriya07082006.html

Ganja use among Jamaican women.
http://www.rism.org/isg/dlp/ganja/a...anjaBabyes.html

Dreher's Jamaican Pregnancy Study
http://www.november.org/stayinfo/br...reherStudy.html

Cannabis Relieves Morning Sickness
http://ccrmg.org/journal/06spr/dreher.html#morning
Moderate cannabis use not harmful to the brain of adolescents, M R I study finds
http://www.cannabis-med.org/english...el.php?id=218#3

No brain structural change associated with adolescent cannabis use
http://www.pubmedcentral.nih.gov/bo...l&artid=1524733

No 'Smoking' Gun: Research Indicates Teen Marijuana Use Does Not Predict Drug, Alcohol Abuse
http://www.sciencedaily.com/release...61204123422.htm

Pot May Not Shrink Teens' Brains After All
http://www.medpagetoday.com/Neurolo...urology/tb/3242

Chronic Cystitis
Cannabinoid rotation in a young woman with chronic cystitis
http://www.cannabis-med.org/studies...ow.php?s_id=115

CPOD

THC effective in appetite and weight loss in severe lung disease (COPD)
http://www.cannabis-med.org/english...el.php?id=191#2

Heavy Long-Term Marijuana Use Does Not Impair Lung Function
http://www.erowid.org/plants/cannab...is_media7.shtml

Diabetes

Cannabinoid Reduces Incidence Of Diabetes
http://www.norml.org/index.cfm?Group_ID=6909

Marijuana Compound May Help Stop Diabetic Retinopathy
http://www.sciencedaily.com/release...60227184647.htm

Cannabidiol lowers incidence of diabetes in non-obese diabetic mice
http://www.ingentaconnect.com/conte...sn7o5efqr.alice

Anticoagulant Effects of a Cannabis Extract in an Obese Rat Model
http://www.level1diet.com/research/id/14687

Neuroprotective and Blood-Retinal Barrier-Preserving Effects of Cannabidiol
http://ajp.amjpathol.org/cgi/content/full/168/1/235

The Cannabinergic System as a Target for Anti-inflammatory Therapies
http://www.ingentaconnect.com/conte...000013/art00008

Effect of tetrahydrocurcumin on blood glucose, plasma insulin and hepatic key enzymes
http://www.unboundmedicine.com/medl...d_diabetic_rats

Cannabidiol reduces the development of diabetes in an animal study
http://www.cannabis-med.org/english...el.php?id=219#3

Depression

Cannabinoids promote hippocampus neurogenesis and produce anxiolytic- and antidepressant
http://www.jci.org/cgi/content/full/115/11/3104

Antidepressant-like activity by blockade of anandamide hydrolysis
http://www.pubmedcentral.nih.gov/ar...bmedid=16352709

Decreased depression in marijuana users.
http://www.medscape.com/medline/abstract/15964704

Antidepressant-like activity
http://www.pubmedcentral.nih.gov/ar...bmedid=16352709

Dronabinol and marijuana in HIV-positive marijuana smokers: caloric intake, mood, and sleep.
http://www.cannabis-med.org/studies...ow.php?s_id=190

Nabilone improves pain and symptom management in cancer patients
http://www.cannabis-med.org/studies...ow.php?s_id=177

The perceived effects of smoked cannabis on patients with multiple sclerosis.
http://www.cannabis-med.org/studies...how.php?s_id=13

Cannabis and Depression
http://www.pacifier.com/~alive/cmu/...nd_cannabis.htm

Association between cannabis use and depression may not be causal, study says
http://www.cannabis-med.org/english...el.php?id=177#4

Marijuana use and depression among adults: Testing for causal associations.
http://www.ncbi.nlm.nih.gov/sites/e...Pubmed_RVDocSum

Do patients use marijuana as an antidepressant?
http://www.ncbi.nlm.nih.gov/sites/e...Pubmed_RVDocSum

Dermatitis

Efficacy of dietary hempseed oil in patients with atopic dermatitis.
http://www.medscape.com/medline/abs...ryText=hempseed

Dronabinol 

Dronabinol in the treatment of agitation in patients with Alzheimer’s disease with anorexia
http://www.cannabis-med.org/studies...how.php?s_id=61

Dronabinol in the treatment of refractory agitation in Alzheimer’s disease
http://www.cannabis-med.org/studies...how.php?s_id=92

Effects of dronabinol on anorexia and disturbed behavior in patients with Alzheimer's disease.
http://www.cannabis-med.org/studies...how.php?s_id=59

Dronabinol an effective appetite stimulant?
http://www.cannabis-med.org/studies...ow.php?s_id=188

Safety and efficacy of dronabinol in the treatment of agitation in patients with Alzheimer’s disease
http://www.cannabis-med.org/studies...how.php?s_id=61

Effect of dronabinol on nutritional status in HIV infection.
http://www.cannabis-med.org/studies...ow.php?s_id=150

Dronabinol stimulates appetite and causes weight gain in HIV patients.
http://www.cannabis-med.org/studies...how.php?s_id=20

Dronabinol effects on weight in patients with HIV infection.
http://www.cannabis-med.org/studies...how.php?s_id=45

Recent clinical experience with dronabinol.
http://www.cannabis-med.org/studies...how.php?s_id=90

Dronabinol enhancement of appetite in cancer patients.
http://www.cannabis-med.org/studies...ow.php?s_id=149

Dronabinol for supportive therapy in patients with malignant melanoma and liver metastases.
http://www.cannabis-med.org/studies...ow.php?s_id=180

Dronabinol and prochlorperazine in combination
http://www.cannabis-med.org/studies...how.php?s_id=28

Dronabinol enhancement of appetite in cancer patients.
http://www.cannabis-med.org/studies...ow.php?s_id=149

Efficacy of dronabinol alone and in combination
http://www.cannabis-med.org/studies...ow.php?s_id=191

Dronabinol and marijuana in HIV-positive marijuana smokers: caloric intake, mood, and sleep.
http://www.cannabis-med.org/studies...ow.php?s_id=190

Dronabinol and retinal hemodynamics in humans.
http://www.cannabis-med.org/studies...ow.php?s_id=202

Dronabinol reduces signs and symptoms of idiopathic intracranial hypertension
http://www.cannabis-med.org/studies...ow.php?s_id=181

Nausea relieved by tetrahydrocannabinol (dronabinol).
http://www.cannabis-med.org/studies...how.php?s_id=35

Dronabinol in patients with intractable pruritus secondary to cholestatic liver disease.
http://www.cannabis-med.org/studies...ow.php?s_id=116

Treatment of spasticity in spinal cord injury with dronabinol
http://www.cannabis-med.org/studies...ow.php?s_id=112

Cannabinoid Activator Mellows Out Colon
http://www.medpagetoday.com/MeetingCoverage/ACG/tb/4410

Drug testing

Hemp oil causes positive urine tests for THC
http://www.druglibrary.org/crl/drug...0JAnToxicol.pdf

Dystonia

Cannabis sativa and dystonia secondary to Wilson's disease.
http://www.medscape.com/medline/abstract/15390041

Experiences with THC-treatment in children and adolescents
http://www.cannabis-med.org/studies...how.php?s_id=80

Evaluation of cannabidiol in dystonic movement disorders
http://www.cannabis-med.org/studies...how.php?s_id=14

Cannabidiol in dystonic movement disorders.
http://www.cannabis-med.org/studies...ow.php?s_id=139

Beneficial and adverse effects of cannabidiol in a Parkinson patient
http://www.cannabis-med.org/studies...ow.php?s_id=142

Treatment of Meige's syndrome with cannabidiol.
http://www.cannabis-med.org/studies...ow.php?s_id=114

Endocannabinoid Deficiency

Clinical Endocannabinoid Deficiency
http://www.freedomtoexhale.com/clinical.pdf

The endocannabinoid system is dysregulated in multiple sclerosis
http://brain.oxfordjournals.org/cgi...stract/awm160v1

Cannabinoids inhibit neurodegeneration in models of multiple sclerosis
http://brain.oxfordjournals.org/cgi...ull/126/10/2191

Epilepsy

Epilepsy patients are smoking pot
http://www.safeaccessnow.org/article.php?id=1638

CANNABIDIOL TO HEALTHY VOLUNTEERS AND EPILEPTIC PATIENTS
http://web.acsalaska.net/~warmgun/es201.html

Experiences with THC-treatment in children and adolescents
http://www.cannabis-med.org/studies...how.php?s_id=80

Chronic administration of cannabidiol to healthy volunteers and epileptic patients.
http://www.cannabis-med.org/studies...how.php?s_id=42

Anticonvulsant nature of marihuana smoking.
http://www.cannabis-med.org/studies...how.php?s_id=39

Cannabis may help epileptics
http://www.medicalnewstoday.com/articles/4423.php

Hypnotic and Antiepileptic Effects of Cannabidiol
http://www.thecompassionclub.org/me...rue&pageNumber=

Marijuana: an effective antiepileptic treatment in partial epilepsy?
http://www.cannabis-med.org/studies...ow.php?s_id=157

Familial Mediterranean Fever

Pain relief with oral cannabinoids in familial Mediterranean fever.
http://www.cannabis-med.org/studies...how.php?s_id=18

Fertility

Synthetic Cannabinoid May Aid Fertility In Smokers
http://www.medicalnewstoday.com/articles/58063.php

Fever

A Novel Role of Cannabinoids
http://ccicnewsletter.com/index.php...nfectious_Disea

A Cooling Effect From Cannabis?
http://ccrmg.org/journal/05aut/coolcannabis.html

Fibromyalgia

Delta-9-THC based monotherapy in fibromyalgia patients
http://www.medscape.com/medline/abstract/16834825

Clinical Endocannabinoid Deficiency
http://www.freedomtoexhale.com/clinical.pdf

Cannabis Sativa (Marijuana) for Fibromyalgia
http://www.fibromyalgia-reviews.com/Drg_Marijuana.cfm

THC Reduces Pain in Fibromyalgia Patients
http://www.illinoisnorml.org/content/view/63/35/

Gateway Theory

The Myth of Marijuana's Gateway Effect
http://www.druglibrary.org/schaffer/library/mjgate.htm

Endogenous cannabinoids are not involved in cocaine reinforcement
http://www.sciencedirect.com/scienc...a4e861a90579fac

No 'Smoking' Gun: Research Indicates Teen Marijuana Use Does Not Predict Drug, Alcohol Abuse
http://www.sciencedaily.com/release...61204123422.htm

CLAIM #13:MARIJUANA IS A "GATEWAY" TO THE USE OF OTHER DRUGS
http://www.erowid.org/plants/cannab...is_myth13.shtml

Glaucoma

Marijuana Smoking vs Cannabinoids for Glaucoma Therapy
http://archopht.ama-assn.org/cgi/co...act/116/11/1433

Dronabinol and retinal hemodynamics in humans.
http://www.cannabis-med.org/studies...ow.php?s_id=202

Effect of Sublingual Application of Cannabinoids on Intraocular Pressure
http://www.cannabis-med.org/studies...ow.php?s_id=201

Delta 9-tetrahydrocannabinol in cancer chemotherapy. Ophthalmologic implications.
http://www.cannabis-med.org/studies...how.php?s_id=88

Effect of marihuana on intraocular and blood pressure in glaucoma.
http://www.cannabis-med.org/studies...how.php?s_id=87

Effect of delta-9-tetrahydrocannabinol on intraocular pressure in humans.
http://www.cannabis-med.org/studies...how.php?s_id=40

Marihuana smoking and intraocular pressure.
http://www.cannabis-med.org/studies...how.php?s_id=47

Neuroprotective and Intraocular Pressure-Lowering Effects of (-)Delta-Tetrahydrocannabinol
http://www.unboundmedicine.com/medl...del_of_Glaucoma

Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol
http://www.unboundmedicine.com/medl...f_peroxynitrite

Effects of tetrahydrocannabinol on arterial and intraocular hypertension.
http://www.medscape.com/medline/abstract/468444

Gynocology and obstetrics
Cannabis Treatments in Obstetrics and Gynecology: A Historical Review
http://www.freedomtoexhale.com/russo-ob.pdf

Heart Disease/ Cardiovascular

Marijuana Chemical Fights Hardened Arteries
http://www.webmd.com/heart-disease/...rdened-arteries

The endogenous cardiac cannabinoid system: a new protective mechanism
http://www.cannabinoid.com/boards/thd3x10073.shtml

Cardiovascular pharmacology of cannabinoids.
http://www.biowizard.com/story.php?pmid=16596789

Delta-9-tetrahydrocannabinol protects cardiac cells from hypoxia
http://www.ingentaconnect.com/conte...020001/00002346

Does Cannabis Hold the Key to Treating Cardiometabolic Disease?
http://www.medscape.com/viewarticle/525040_print

Cannabinoid Offers Cardioprotection
http://www.norml.org/index.cfm?Grou...tm_format=print

Heavy Cannabis Use Not Independently Associated With Cardiovascular Risks
http://www.norml.org/index.cfm?Group_ID=6972

Marijuana use, diet, body mass index, and cardiovascular risk factors
http://www.medscape.com/medline/abstract/16893701

Cannabinoids and cardiovascular disease
http://www.unboundmedicine.com/medl...ical_treatments

Cannabinoids as therapeutic agents in cardiovascular disease
http://www.unboundmedicine.com/medl...s_and_illusions

The in vitro and in vivo cardiovascular effects of {Delta}9-tetrahydrocannabinol
http://www.unboundmedicine.com/medl..._oxide_synthase

Cannabinoids prevented the development of heart failure in animal study
http://www.cannabis-med.org/english...el.php?id=145#2

Cannabis use not associated with risk factors for diseases of heart and circulation
http://www.cannabis-med.org/english...el.php?id=225#2

THC protects heart cells in the case of lowered oxygen supply
http://www.cannabis-med.org/english...el.php?id=212#1

Medical marijuana: study shows that THC slows atherosclerosis
http://thenexthurrah.typepad.com/th...al_marijua.html

Cardiovascular Effects of Cannabis
http://www.idmu.co.uk/canncardio.htm

Changes in middle cerebral artery velocity after marijuana
http://www.ncbi.nlm.nih.gov/sites/e...0&dopt=Abstract[/]

Hepatitis 

Moderate Cannabis Use Associated with Improved Treatment Response
http://www.hivandhepatitis.com/hep_...6/091506_a.html

Cannabis use improves retention and virological outcomes in patients treated for hepatitis C
http://www.natap.org/2006/HCV/091506_02.htm

Hepatitis C - The Silent Killer Can Medical Cannabis Help?
http://www.pacifier.com/~alive/cmu/hepatitis_c.htm

Herpes

Cannabis May Help Combat Cancer-causing Herpes Viruses
http://www.sciencedaily.com/release...40923092627.htm

THC inhibits lytic replication of gamma oncogenic herpes viruses in vitro
http://www.pubmedcentral.nih.gov/bo...ml&artid=521080

Suppressive effect of delta-9-tetrahydrocannabinol on herpes simplex virus infectivity in vitro
http://www.ebmonline.org/cgi/content/abstract/196/4/401

Inhibition of cell-associated herpes simplex virus
http://www.ebmonline.org/cgi/content/abstract/185/1/41

The Effect of {Delta}-9-Tetrahydrocannabinol on Herpes Simplex Virus Replication
http://vir.sgmjournals.org/cgi/cont...stract/49/2/427

Hiccups

Marijuana cures hiccups
http://www.yourhealthbase.com/database/a77k.htm

Marijuana For Intractable Hiccups
http://cannabislink.ca/medical/hiccups.html

HIV / AIDS

Marijuana Use Does Not Accelerate HIV Infection
http://paktribune.com/news/print.php?id=139255

THC improves appetite and reverses weight loss in AIDS patients
http://www.cannabis-med.org/studies...ow.php?s_id=189

Dronabinol and marijuana in HIV-positive marijuana smokers: caloric intake, mood, and sleep.
http://www.cannabis-med.org/studies...ow.php?s_id=190

Cannabis in painful HIV-associated sensory neuropathy
http://www.cannabis-med.org/studies...ow.php?s_id=199

Smoked cannabis therapy for HIV-related painful peripheral neuropathy
http://www.cannabis-med.org/studies...ow.php?s_id=172

Short-term effects of cannabinoids in patients with HIV-1 infection
http://www.cannabis-med.org/studies...how.php?s_id=62

Dronabinol as a treatment for anorexia associated with weight loss in patients with AIDS.
http://www.cannabis-med.org/studies...how.php?s_id=21

Effect of dronabinol on nutritional status in HIV infection.
http://www.cannabis-med.org/studies...ow.php?s_id=150

Dronabinol stimulates appetite and causes weight gain in HIV patients.
http://www.cannabis-med.org/studies...how.php?s_id=20

Dronabinol effects on weight in patients with HIV infection.
http://www.cannabis-med.org/studies...how.php?s_id=45

Recent clinical experience with dronabinol.
http://www.cannabis-med.org/studies...how.php?s_id=90

Marijuana as therapy for people living with HIV/AIDS: Social and health aspects
http://www.unboundmedicine.com/medl..._health_aspects

Marijuana and AIDS: A Four-Year Study
http://ccrmg.org/journal/05spr/aids.html

Historical studies

The La Guardia Committee Report
http://www.druglibrary.org/schaffer...lag/lagmenu.htm

Physical, Mental, and Moral Effects of Marijuana: The Indian Hemp Drugs Commission Report
http://www.druglibrary.org/schaffer/Library/effects.htm

MARIAJUANA SMOKING IN PANAMA
http://www.druglibrary.org/schaffer...ama/panama1.htm

The British Pharmaceutical Codex – 1934
http://www.druglibrary.org/schaffer...ical/brit34.htm

ON THE PREPARATIONS OF THE INDIAN HEMP, OR GUNJAH
http://www.druglibrary.org/schaffer...1850/gunjah.htm

DISPENSATORY OF THE UNITED STATES OF AMERICA Fifth Edition (1843)
http://www.druglibrary.org/schaffer...ry/dispensa.htm

New Remedies:Pharmaceutically and Therapeutically Considered Fourth Edition (1843)
http://www.druglibrary.org/schaffer...ry/dunglisn.htm

On the Haschisch or Cannabis Indica
http://www.druglibrary.org/schaffer...ry/bellhash.htm

ON INDICATIONS OF THE HACHISH-VICE IN THE OLD TESTAMENT
http://www.druglibrary.org/schaffer...tory/hashot.htm

The Physiological Activity of Cannabis Sativa
http://www.druglibrary.org/schaffer...istory/japa.htm

CANNABIS, U.S.P. (American Cannabis):
http://www.druglibrary.org/schaffer...ry/vbchmed1.htm

Hormones

Effects of chronic marijuana use on testosterone, luteinizing hormone, follicle stimulating …
http://www.anesth.uiowa.edu/readabs...sp?PMID=1935564

Marijuana: interaction with the estrogen receptor
http://jpet.aspetjournals.org/cgi/c...tract/224/2/404

Huntington’s Disease

EFFECTS OF CANNABIDIOL IN HUNTINGTON'S DISEASE
http://www.druglibrary.org/schaffer...al/hunting1.htm

Nabilone Could Treat Chorea and Irritability in Huntington’s Disease
http://neuro.psychiatryonline.org/c.../18/4/553?rss=1

Hysterectomy
Effect of nabilone on nausea and vomiting after total abdominal hysterectomy
http://www.cannabis-med.org/studies...ow.php?s_id=137

Idiopathic Intracranial Hypertension
Dronabinol reduces signs and symptoms of idiopathic intracranial hypertension
http://www.cannabis-med.org/studies...ow.php?s_id=181
IQ
Findings of a longitudinal study of effects on IQ
http://www.cmaj.ca/cgi/content/full/166/7/887

Heavy cannabis use without long-term effect on global intelligence
http://www.cannabis-med.org/english...el.php?id=115#2

Marijuana does not dent IQ permanently
http://www.newscientist.com/article...ermanently.html

Marinol/Synthetics/ cannabinoid mixtures 

CANNABIS AND MARINOL IN THE TREATMENT OF MIGRAINE HEADACHE
http://www.druglibrary.org/schaffer/hemp/migrn2.htm

Marinol vs Natural Cannabis
http://www.norml.org/pdf_files/NORM...al_Cannabis.pdf

The therapeutic rationale for combining tetrahydrocannabinol and cannabidiol.
http://www.medscape.com/medline/abstract/16209908

Unheated Cannabis sativa extracts and its major compound THC-acid
http://www.medscape.com/medline/abs...504929?prt=true

Side effects of pharmaceuticals not elicited by comparable herbal medicines.
http://www.medscape.com/medline/abstract/10394675

Sativex in the treatment of pain caused by rheumatoid arthritis
http://rheumatology.oxfordjournals....bstract/45/1/50
Is dronabinol an effective appetite stimulant?
http://www.cannabis-med.org/studies...ow.php?s_id=188

Sativex in patients suffering from multiple sclerosis associated detrusor overactivity
http://www.cannabis-med.org/studies...ow.php?s_id=168

Sativex® in patients with symptoms of spasticity due to multiple sclerosis
http://www.cannabis-med.org/studies...ow.php?s_id=169

Nabilone improves pain and symptom management in cancer patients
http://www.cannabis-med.org/studies...ow.php?s_id=177

Dronabinol for supportive therapy in patients with malignant melanoma and liver metastases
http://www.cannabis-med.org/studies...ow.php?s_id=180

Synthetic cannabinomimetic nabilone on patients with chronic pain
http://www.cannabis-med.org/studies...ow.php?s_id=197

Nabilone significantly reduces spasticity-related pain
http://www.cannabis-med.org/studies...ow.php?s_id=200

Sativex produced significant improvements in a subjective measure of spasticity
http://www.cannabis-med.org/studies...ow.php?s_id=170

Analgesic effect of the synthetic cannabinoid CT-3 on chronic neuropathic pain
http://www.cannabis-med.org/studies...how.php?s_id=85

Cannabinoid rotation in a young woman with chronic cystitis
http://www.cannabis-med.org/studies...ow.php?s_id=115

Dronabinol in patients with intractable pruritus
http://www.cannabis-med.org/studies...ow.php?s_id=116

Cannabinoids reduce levodopa-induced dyskinesia in Parkinson's disease:
http://www.cannabis-med.org/studies...how.php?s_id=54

Nabilone on L-DOPA induced dyskinesia in patients with idiopathic Parkinson's disease
http://www.cannabis-med.org/studies...ow.php?s_id=153

Nabilone in the treatment of multiple sclerosis.
http://www.cannabis-med.org/studies...how.php?s_id=11

Big Pharma's Strange Holy Grail: Cannabis Without Euphoria?
http://www.counterpunch.org/gardner07082006.html

Sativex showed positive effects in 65 per cent of patients with chronic diseases
http://www.cannabis-med.org/english...el.php?id=230#4
Meige’s Syndrome
Treatment of Meige's syndrome with cannabidiol.
http://www.cannabis-med.org/studies...ow.php?s_id=114

Migraine/ Headache

CANNABIS AND MARINOL IN THE TREATMENT OF MIGRAINE HEADACHE
http://www.druglibrary.org/schaffer/hemp/migrn2.htm

Dronabinol reduces signs and symptoms of idiopathic intracranial hypertension
http://www.cannabis-med.org/studies...ow.php?s_id=181

Cannabis and Migraine
http://www.pacifier.com/~alive/cmu/...nd_migraine.htm

Clinical Endocannabinoid Deficiency
http://www.freedomtoexhale.com/clinical.pdf

Hemp for Headache
http://www.freedomtoexhale.com/hh.pdf

Chronic Migraine Headache
http://www.druglibrary.org/schaffer/hemp/migrn1.htm

Morning Sickness

Medical marijuana: a surprising solution to severe morning sickness http://www.findarticles.com/p/artic...124/ai_n6015580

Medicinal cannabis use among childbearing women
http://safeaccess.ca/research/cannabis_nausea2006.pdf

Mortality Rates
Marijuana use and mortality.
http://www.pubmedcentral.nih.gov/ar...i?artid=1380837

Marijuana Smoking Doesn't Lead to Higher Death Rate
http://ccrmg.org/journal/03sum/kaiser.html

How deadly is marijuana?
http://www.medicalnewstoday.com/articles/4426.php

MS

Sativex in patients with symptoms of spasticity due to multiple sclerosis
http://www.cannabis-med.org/studies...ow.php?s_id=169

Marijuana derivatives may provide MS treatment
http://www.healthypages.net/news.asp?newsid=5381

Marijuana Helps MS Patients Alleviate Pain, Spasms
http://www.mult-sclerosis.org/news/...smsAndPain.html

Cannabis-based medicine in central pain in multiple sclerosis
http://www.neurology.org/cgi/conten...t/65/6/812?etoc

Cannabis-based medicine in spasticity caused by multiple sclerosis
http://www.cannabis-med.org/studies...ow.php?s_id=192

Sativex in patients suffering from multiple sclerosis associated detrusor overactivity
http://www.cannabis-med.org/studies...ow.php?s_id=168

The effect of cannabis on urge incontinence in patients with multiple sclerosis
http://www.cannabis-med.org/studies...ow.php?s_id=185

Nabilone significantly reduces spasticity-related pain
http://www.cannabis-med.org/studies...ow.php?s_id=200

Cannabinoids in multiple sclerosis (CAMS) study
http://www.cannabis-med.org/studies...ow.php?s_id=160

Sativex produced significant improvements in a subjective measure of spasticity
http://www.cannabis-med.org/studies...ow.php?s_id=170

Cannabis-based medicine in central pain in multiple sclerosis.
http://www.cannabis-med.org/studies...ow.php?s_id=175

Do cannabis-based medicinal extracts have general or specific effects
http://www.cannabis-med.org/studies...how.php?s_id=56

Efficacy, safety and tolerability of an oral cannabis extract in the treatment of spasticity
http://www.cannabis-med.org/studies...how.php?s_id=63

cannabis-based extracts for bladder dysfunction in advanced multiple sclerosis.
http://www.cannabis-med.org/studies...how.php?s_id=81

Are oral cannabinoids safe and effective in refractory neuropathic pain?
http://www.cannabis-med.org/studies...ow.php?s_id=143

Dronabinol in the treatment of agitation in patients with Alzheimer’s disease with anorexia
http://www.cannabis-med.org/studies...how.php?s_id=61

Cannabis based medicinal extracts (CBME) in central neuropathic pain due to multiple sclerosis.
http://www.cannabis-med.org/studies...how.php?s_id=82

Cannabinoids for treatment of spasticity and other symptoms related to multiple sclerosis
http://www.cannabis-med.org/studies...ow.php?s_id=108

Cannabis based medicinal extract on refractory lower urinary tract dysfunction
http://www.cannabis-med.org/studies...ow.php?s_id=103

Analgesic effect of the cannabinoid analogue nabilone
http://www.cannabis-med.org/studies...ow.php?s_id=203

The perceived effects of smoked cannabis on patients with multiple sclerosis.
http://www.cannabis-med.org/studies...how.php?s_id=13

Orally and rectally administered delta-9-tetrahydrocannabinol on spasticity
http://www.cannabis-med.org/studies...how.php?s_id=12

Nabilone in the treatment of multiple sclerosis
http://www.cannabis-med.org/studies...how.php?s_id=11

Effect of cannabinoids on spasticity and ataxia in multiple sclerosis.
http://www.cannabis-med.org/studies...show.php?s_id=2

Delta-9-THC in the treatment of spasticity associated with multiple sclerosis.
http://www.cannabis-med.org/studies...show.php?s_id=1

Tetrahydrocannabinol for tremor in multiple sclerosis.
http://www.cannabis-med.org/studies...show.php?s_id=9

Marihuana as a therapeutic agent for muscle spasm or spasticity
http://www.cannabis-med.org/studies...how.php?s_id=53

Cannabis-based medicine in spasticity caused by multiple sclerosis.
http://www.unboundmedicine.com/medl...tiple_sclerosis

Cannabis based treatments for neuropathic and multiple sclerosis-related pain.
http://www.unboundmedicine.com/medl...is_related_pain

The effect of cannabis on urge incontinence in patients with multiple sclerosis
http://www.unboundmedicine.com/medl...ial__CAMS_LUTS_

Can Cannabis Help Multiple Sclerosis? An International Debate Rages
http://www.pacifier.com/~alive/cmu/...bis_help_ms.htm
Cannabis' Potential Exciting Researchers in Treatment of ALS, Parkinson's Disease
http://66.218.69.11/search/cache?ei...&icp=1&.intl=us

The endocannabinoid system is dysregulated in multiple sclerosis
http://brain.oxfordjournals.org/cgi...stract/awm160v1

Cannabinoids inhibit neurodegeneration in models of multiple sclerosis
http://brain.oxfordjournals.org/cgi...ull/126/10/2191

Nabilone
The synthetic cannabinoid nabilone improves pain and symptom management in cancer patients
http://www.cannabis-med.org/studies...ow.php?s_id=177

Nabilone versus prochlorperazine
http://www.cannabis-med.org/studies...ow.php?s_id=120

Nabilone: an alternative antiemetic for cancer chemotherapy.
http://www.cannabis-med.org/studies...ow.php?s_id=123

Antiemetic efficacy of nabilone and alizapride
http://www.cannabis-med.org/studies...ow.php?s_id=127

Nabilone versus domperidone
http://www.cannabis-med.org/studies...ow.php?s_id=129

Comparison of nabilone and prochlorperazine
http://www.cannabis-med.org/studies...ow.php?s_id=128

Nabilone vs. prochlorperazine for refractory emesis
http://www.cannabis-med.org/studies...ow.php?s_id=146

Nabilone vs. placebo
http://www.cannabis-med.org/studies...ow.php?s_id=156

Effects of nabilone and prochlorperazine on chemotherapy-induced emesis
http://www.cannabis-med.org/studies...ow.php?s_id=131

Superiority of nabilone over prochlorperazine
http://www.cannabis-med.org/studies...ow.php?s_id=126

Nabilone versus prochlorperazine for control of cancer chemotherapy-induced emesis in children
http://www.cannabis-med.org/studies...ow.php?s_id=120

Nabilone: an alternative antiemetic for cancer chemotherapy.
http://www.cannabis-med.org/studies...ow.php?s_id=123

Effect of nabilone on nausea and vomiting after total abdominal hysterectomy
http://www.cannabis-med.org/studies...ow.php?s_id=137

Nabilone improves pain and symptom management in cancer patients
http://www.cannabis-med.org/studies...ow.php?s_id=177

Synthetic cannabinomimetic nabilone on patients with chronic pain
http://www.cannabis-med.org/studies...ow.php?s_id=197

Nabilone significantly reduces spasticity-related pain
http://www.cannabis-med.org/studies...ow.php?s_id=200

Nabilone on L-DOPA induced dyskinesia in patients with idiopathic Parkinson's disease
http://www.cannabis-med.org/studies...ow.php?s_id=153

Nabilone in the treatment of multiple sclerosis.
http://www.cannabis-med.org/studies...how.php?s_id=11

Nabilone significantly reduces spasticity-related pain
http://www.cannabis-med.org/studies...ow.php?s_id=200

Analgesic effect of the cannabinoid analogue nabilone
http://www.cannabis-med.org/studies...ow.php?s_id=203

Nabilone in the treatment of multiple sclerosis
http://www.cannabis-med.org/studies...how.php?s_id=11

Comparison of nabilone and metoclopramide in the control of radiation-induced nausea.
http://www.cannabis-med.org/studies...ow.php?s_id=130

Nabilone and metoclopramide in the treatment of nausea and vomiting
http://www.cannabis-med.org/studies...ow.php?s_id=121

Nabilone: an alternative antiemetic for cancer chemotherapy.
http://www.cannabis-med.org/studies...ow.php?s_id=123

Comparison of the antiemetic efficacy of nabilone and alizapride
http://www.cannabis-med.org/studies...ow.php?s_id=127

Nabilone versus domperidone in the treatment of cytotoxic-induced emesis.
http://www.cannabis-med.org/studies...ow.php?s_id=129

Add-on treatment with the synthetic cannabinomimetic nabilone on patients with chronic pain -
http://www.cannabis-med.org/studies...ow.php?s_id=197

Comparison of bronchial effects of nabilone and terbutaline
http://www.cannabis-med.org/studies...how.php?s_id=43

Nabilone Could Treat Chorea and Irritability in Huntington’s Disease
http://neuro.psychiatryonline.org/c.../18/4/553?rss=1

Nausea 
THC improves appetite and reverses weight loss in AIDS patients
http://www.cannabis-med.org/studies...ow.php?s_id=189

Efficacy of dronabinol alone and in combination with ondansetron versus ondansetron alone
http://www.cannabis-med.org/studies...ow.php?s_id=191

Dronabinol and marijuana in HIV-positive marijuana smokers: caloric intake, mood, and sleep.
http://www.cannabis-med.org/studies...ow.php?s_id=190

Nabilone improves pain and symptom management in cancer patients
http://www.cannabis-med.org/studies...ow.php?s_id=177

Dronabinol for supportive therapy in patients with malignant melanoma and liver metastases.
http://www.cannabis-med.org/studies...ow.php?s_id=180

Nausea relieved by tetrahydrocannabinol (dronabinol).
http://www.cannabis-med.org/studies...how.php?s_id=35

An efficient new cannabinoid antiemetic in pediatric oncology.
http://www.cannabis-med.org/studies...show.php?s_id=7

Effect of nabilone on nausea and vomiting after total abdominal hysterectomy.
http://www.cannabis-med.org/studies...ow.php?s_id=137

Marijuana as antiemetic medicine
http://www.cannabis-med.org/studies...ow.php?s_id=134

Efficacy of tetrahydrocannabinol in patients refractory to standard anti-emetic therapy
http://www.cannabis-med.org/studies...how.php?s_id=31

Inhalation marijuana as an antiemetic for cancer chemotherapy.
http://www.cannabis-med.org/studies...ow.php?s_id=155

Nabilone versus prochlorperazine for control of cancer chemotherapy-induced emesis in children
http://www.cannabis-med.org/studies...ow.php?s_id=120
Comparison of nabilone and metoclopramide in the control of radiation-induced nausea.
http://www.cannabis-med.org/studies...ow.php?s_id=130

Nabilone and metoclopramide in the treatment of nausea and vomiting
http://www.cannabis-med.org/studies...ow.php?s_id=121

Nabilone: an alternative antiemetic for cancer chemotherapy.
http://www.cannabis-med.org/studies...ow.php?s_id=123

Comparison of the antiemetic efficacy of nabilone and alizapride
http://www.cannabis-med.org/studies...ow.php?s_id=127

Nabilone versus domperidone in the treatment of cytotoxic-induced emesis.
http://www.cannabis-med.org/studies...ow.php?s_id=129

THC or Compazine for the cancer chemotherapy patient--the UCLA study
http://www.cannabis-med.org/studies...how.php?s_id=34

Comparison of nabilone and prochlorperazine for emesis induced by cancer chemotherapy.
http://www.cannabis-med.org/studies...ow.php?s_id=128

Acute and subacute bronchial effects of oral cannabinoids.
http://www.cannabis-med.org/studies...how.php?s_id=44

Nabilone vs. prochlorperazine for refractory emesis induced by cancer chemotherapy.
http://www.cannabis-med.org/studies...ow.php?s_id=146

Nabilone vs. placebo in chemotherapy-induced nausea and vomiting.
http://www.cannabis-med.org/studies...ow.php?s_id=156

Dose vs response of tetrahydroannabinol (THC) vs prochlorperazine
http://www.cannabis-med.org/studies...how.php?s_id=30 delta 9-

Comparative trial of the antiemetic effects of THC and haloperidol
http://www.cannabis-med.org/studies...how.php?s_id=64

Comparison of delta-9-tetrahydrocannabinol and prochlorperazine.
http://www.cannabis-med.org/studies...show.php?s_id=3

Tetrahydrocannabinol in cancer chemotherapy. Ophthalmologic implications.
http://www.cannabis-med.org/studies...how.php?s_id=88

Antiemetic effect of tetrahydrocannabinol
http://www.cannabis-med.org/studies...show.php?s_id=6

The antiemetic activity of tetrahydrocanabinol versus metoclopramide and thiethylperazine
http://www.cannabis-med.org/studies...how.php?s_id=24

The antiemetic effects of nabilone and prochlorperazine on chemotherapy-induced emesis.
http://www.cannabis-med.org/studies...ow.php?s_id=131

Delta-9-tetrahydrocannabinol as an antiemetic for patients receiving cancer chemotherapy
http://www.cannabis-med.org/studies...show.php?s_id=5

Delta-9-tetrahydrocannabinol as an antiemetic in cancer patients receiving high-dose methotrexate
http://www.cannabis-med.org/studies...how.php?s_id=23

THC as an antiemetic in patients treated with cancer chemotherapy
http://www.cannabis-med.org/studies...how.php?s_id=27

Amelioration of cancer chemotherapy-induced nausea and vomiting by delta-9-THC.
http://www.cannabis-med.org/studies...ow.php?s_id=107

Superiority of nabilone over prochlorperazine as an antiemetic
http://www.cannabis-med.org/studies...ow.php?s_id=126

Antiemetic effect of delta-9-tetrahydrocannabinol in patients receiving cancer chemotherapy.
http://www.cannabis-med.org/studies...show.php?s_id=4

Receptor mechanism and antiemetic activity of structurally-diverse cannabinoids
http://www.unboundmedicine.com/medl...the_least_shrew

Neurons
Marijuana Promotes Neuron Growth
http://www.medpot.net/forums/index.php?showtopic=27460

Marijuana-Like Chemicals in the Brain Calm Neurons
http://www.medpot.net/forums/index.php?showtopic=9686

Marijuana May Spur New Brain Cells
http://www.treatingyourself.com/vbu...read.php?t=5921

Cannabinoids promote embryonic and adult hippocampus neurogenesis
http://www.jci.org/cgi/content/full/115/11/3104
Neuropathic pain 
Cannabinoids Among Most Promising Approaches to Treating Neuropathic Pain
http://www.redorbit.com/news/health...source=r_health

Cannabis-based medicine in central pain in multiple sclerosis
http://www.neurology.org/cgi/conten...t/65/6/812?etoc

Cannabis in painful HIV-associated sensory neuropathy
http://www.cannabis-med.org/studies...ow.php?s_id=199

Smoked cannabis therapy for HIV-related painful peripheral neuropathy
http://www.cannabis-med.org/studies...ow.php?s_id=172

Two cannabis based medicinal extracts for relief of central neuropathic pain
http://www.cannabis-med.org/studies...ow.php?s_id=143

Cannabis based medicinal extracts (CBME) in central neuropathic pain due to multiple sclerosis.
http://www.cannabis-med.org/studies...how.php?s_id=82

Analgesic effect of the synthetic cannabinoid CT-3 on chronic neuropathic pain
http://www.cannabis-med.org/studies...how.php?s_id=85

Smoked cannabis in painful peripheral neuropathy and cancer pain refractory to opiods.
http://www.cannabis-med.org/studies...how.php?s_id=96

Analgesic effect of the cannabinoid analogue nabilone
http://www.cannabis-med.org/studies...ow.php?s_id=203

The perceived effects of smoked cannabis on patients with multiple sclerosis.
http://www.cannabis-med.org/studies...how.php?s_id=13

Cannabis based treatments for neuropathic and multiple sclerosis-related pain.
http://www.unboundmedicine.com/medl...is_related_pain

Neuroprotectant
Marijuana Protects Your Brain
http://www.roninpub.com/art-mjbrain.html

The neuroprotective effect of cannabinoids in a rat model of Parkinson's disease
http://www.medscape.com/medline/abstract/17196181

Neuroprotective and Intraocular Pressure-Lowering Effects of (-)Delta-THC
http://www.unboundmedicine.com/medl...del_of_Glaucoma

Neuroprotective effect of (-)Delta9-tetrahydrocannabinol and cannabidiol
http://www.unboundmedicine.com/medl...f_peroxynitrite

Neuroprotection induced by Delta(9)-tetrahydrocannabinol in AF5 cells
http://www.unboundmedicine.com/medl...ol_in_AF5_cells

Cannabidiol has a cerebroprotective action
http://www.unboundmedicine.com/medl...iting_mechanism

Cannabidiol but not Delta(9)-THC has a neuroprotective effect without the development of tolerance..
http://www.unboundmedicine.com/medl...nt_of_tolerance

Delta(9)-THC) prevents cerebral infarction
http://www.unboundmedicine.com/medl...ent_hypothermia

Delta(9)-Tetrahydrocannabinol protects hippocampal neurons from excitotoxicity
http://www.unboundmedicine.com/medl..._excitotoxicity

Cannabis and Neuroprotection
http://www.pacifier.com/~alive/cmu/...oprotection.htm

Nutrition
Oily fish makes 'babies brainier'
http://news.bbc.co.uk/2/hi/health/4631006.stm

Efficacy of dietary hempseed oil in patients with atopic dermatitis.
http://www.medscape.com/medline/abs...ryText=hempseed

Effects of smoked marijuana on food intake and body weight
http://www.cannabis-med.org/studies...ow.php?s_id=117

Obesity
Does Cannabis Hold the Key to Treating Cardiometabolic Disease?
http://www.medscape.com/viewarticle/525040_print

Effects of smoked marijuana on food intake and body weight
http://www.cannabis-med.org/studies...ow.php?s_id=117

Osteoporosis
Prototype drug to prevent osteoporosis based on cannabinoids
http://www.news-medical.net/?id=15220

Hebrew U. Researchers Find Cannabis Can Strengthen Bones
http://www.israelnationalnews.com/News/News.aspx/96146

Peripheral cannabinoid receptor, CB2, regulates bone mass
http://www.pnas.org/cgi/content/abstract/103/3/696

New Weapon In Battle Against Osteoporosis
http://www.medicalnewstoday.com/articles/35621.php

Activation of CB2 receptor attenuates bone loss in osteoporosis
http://www.cannabis-med.org/english...el.php?id=210#2

Pain-
Cannabis effective at relieving pain after major surgery
http://www.news-medical.net/?id=17995

Cannabinoids, in combination with (NSAIDS), produce a synergistic analgesic effect
http://www.medjournal.com/forum/sho...587&postcount=1

Cannabinoids Among Most Promising Approaches to Treating Neuropathic Pain,
http://www.redorbit.com/news/health...source=r_health

Cannabinoid analgesia as a potential new therapeutic option
http://www.medscape.com/medline/abstract/16449552

Analgesic and adverse effects of an oral cannabis extract (Cannador) for postoperative pain
http://www.cannabis-med.org/studies...ow.php?s_id=184

Delta-9-THC based monotherapy in fibromyalgia patients
http://www.cannabis-med.org/studies...ow.php?s_id=194

Add-on treatment with the synthetic cannabinomimetic nabilone on patients with chronic pain -
http://www.cannabis-med.org/studies...ow.php?s_id=197

Nabilone significantly reduces spasticity-related pain
http://www.cannabis-med.org/studies...ow.php?s_id=200

Synergistic affective analgesic interaction between delta-9-tetrahydrocannabinol and morphine.
http://www.cannabis-med.org/studies...ow.php?s_id=178

Are oral cannabinoids safe and effective in refractory neuropathic pain?
http://www.cannabis-med.org/studies...ow.php?s_id=143

Dronabinol in the treatment of agitation in patients with Alzheimer’s disease with anorexia
http://www.cannabis-med.org/studies...how.php?s_id=61

Cannabis use for chronic non-cancer pain
http://www.cannabis-med.org/studies...how.php?s_id=91

Tetrahydrocannabinol for treatment of chronic pain
http://www.cannabis-med.org/studies...ow.php?s_id=147

Analgesic effect of the cannabinoid analogue nabilone
http://www.cannabis-med.org/studies...ow.php?s_id=203

The perceived effects of smoked cannabis on patients with multiple sclerosis.
http://www.cannabis-med.org/studies...how.php?s_id=13

Pain relief with oral cannabinoids in familial Mediterranean fever.
http://www.cannabis-med.org/studies...how.php?s_id=18

The effect of orally and rectally administered delta-9-tetrahydrocannabinol on spasticity
http://www.cannabis-med.org/studies...how.php?s_id=12

Marihuana as a therapeutic agent for muscle spasm or spasticity.
http://www.cannabis-med.org/studies...how.php?s_id=53

Analgesic effect of delta-9-tetrahydrocannabinol.
http://www.cannabis-med.org/studies...how.php?s_id=16

The analgesic properties of delta-9-tetrahydrocannabinol and codeine.
http://www.cannabis-med.org/studies...how.php?s_id=17

Most pain patients gain benefit from cannabis in a British study
http://www.cannabis-med.org/english...kel.php?id=84#1

Parkinson’s Disease
Marijuana Compounds May Aid Parkinson's Disease
http://cannabisnews.com/news/19/thread19725.shtml

Marijuana-Like Chemicals Helps Treat Parkinson's
http://cannabisnews.com/news/22/thread22608.shtml

Cannabis use in Parkinson's disease: subjective improvement of motor symptoms.
http://www.cannabis-med.org/studies...how.php?s_id=33

Cannabinoids reduce levodopa-induced dyskinesia in Parkinson's disease
http://www.cannabis-med.org/studies...how.php?s_id=54

Nabilone on L-DOPA induced dyskinesia in patients with idiopathic Parkinson's disease
http://www.cannabis-med.org/studies...ow.php?s_id=153

Evaluation of cannabidiol in dystonic movement disorders.
http://www.cannabis-med.org/studies...how.php?s_id=14

Beneficial and adverse effects of cannabidiol in a Parkinson patient
http://www.cannabis-med.org/studies...ow.php?s_id=142

Neuroprotective effect of cannabinoids in a rat model of Parkinson's disease
http://www.medscape.com/medline/abstract/17196181

Post Traumatic Stress Disorder
IDF TO TREAT SHELL SHOCK WITH CANNABIS
http://www.onlinepot.org/medical/id...sshellshock.htm

Study: Marijuana Eases Traumatic Memories
http://cannabisnews.com/news/13/thread13601.shtml

Medical Marijuana: PTSD Medical Malpractice
http://salem-news.com/articles/june...veque_61407.php

Cannabis for the Wounded - Another Walter Reed Scandal
http://www.libertypost.org/cgi-bin/...=179973&Disp=11

PTSD and Cannabis: A Clinician Ponders Mechanism of Action
http://ccrmg.org/journal/06spr/perspective2.html

Cannabis Eases Post Traumatic Stress
http://ccrmg.org/journal/06spr/ptsd.html

Endocannabinoids extinguish bad memories in the brain
http://www.cannabis-med.org/english...el.php?id=123#1

Natural high helps banish bad memories
http://www.newscientist.com/article...d-memories.html

Pregnancy
Oily fish makes 'babies brainier'
http://news.bbc.co.uk/2/hi/health/4631006.stm

Ganja use among Jamaican women.
http://www.rism.org/isg/dlp/ganja/a...anjaBabyes.html

Dreher's Jamaican Pregnancy Study
http://www.november.org/stayinfo/br...reherStudy.html

Cannabis Relieves Morning Sickness
http://ccrmg.org/journal/06spr/dreher.html#morning

Prenatal Marijuana Exposure and Neonatal Outcomes in Jamaica
http://www.druglibrary.org/Schaffer.../can-babies.htm

The Endocannabinoid-CB Receptor System
http://www.nel.edu/pdf_/25_12/NEL251204A01_Fride_.pdf

CLAIM #7: MARIJUANA USE DURING PREGNANCY HARMS THE FETUS
http://www.erowid.org/plants/cannab...bis_myth7.shtml

Prenatal exposure
Prenatal Marijuana Exposure and Neonatal Outcomes in Jamaica
http://www.druglibrary.org/Schaffer.../can-babies.htm

The Endocannabinoid-CB Receptor System
http://www.nel.edu/pdf_/25_12/NEL251204A01_Fride_.pdf

Ganja use among Jamaican women.
http://www.rism.org/isg/dlp/ganja/a...anjaBabyes.html

Dreher's Jamaican Pregnancy Study
http://www.november.org/stayinfo/br...reherStudy.html

Nonmutagenic action of cannabinoids in vitro
http://trophort.com/005/993/005993433.html

Prenatal exposure to tobacco, alcohol, cannabis and caffeine on birth size and subsequent growth.
http://www.ncbi.nlm.nih.gov/sites/e...st_uids=3657756

Tobacco and marijuana use on offspring growth from birth through 3 years of age.
http://www.ncbi.nlm.nih.gov/sites/e...Pubmed_RVDocSum

Prenatal marijuana use and neonatal outcome.
http://www.ncbi.nlm.nih.gov/sites/e...Pubmed_RVDocSum

Pruritis 
Cream with endocannabinoids effective in the treatment of pruritus
http://bbsnews.net/article.php/20051211212223236/print

Topical cannabinoid agonists : An effective new possibility for treating chronic pruritus.
http://www.cannabis-med.org/studies...ow.php?s_id=196

Dronabinol in patients with intractable pruritus secondary to cholestatic liver disease.
http://www.cannabis-med.org/studies...ow.php?s_id=116

Sativex
Sativex in the treatment of pain caused by rheumatoid arthritis
http://rheumatology.oxfordjournals....bstract/45/1/50

Sativex produced significant improvements in a subjective measure of spasticity
http://www.cannabis-med.org/studies...ow.php?s_id=170

Sativex in patients suffering from multiple sclerosis
http://www.cannabis-med.org/studies...ow.php?s_id=168

Sativex in patients suffering from multiple sclerosis associated detrusor overactivity
http://www.cannabis-med.org/studies...ow.php?s_id=168

Sativex showed positive effects in 65 per cent of patients with chronic diseases
http://www.cannabis-med.org/english...el.php?id=230#4

Schizophrenia/ Mental disorders
Increased cannabinoid receptor density in the posterior cingulate cortex in schizophrenia.
http://www.medscape.com/medline/abstract/16710682

Symptoms of schizotypy precede cannabis use.
http://www.ukcia.org/forum/read.php?7,7543,7579

Cannabidiol as an antipsychotic
http://www.cannabis-med.org/studies...ow.php?s_id=171

Anandamide levels in cerebrospinal fluid of first-episode schizophrenic patients
http://www.unboundmedicine.com/medl...of_cannabis_use

Delta-9-Tetrahydrocannabinol-Induced Effects on Psychosis and Cognition
http://www.unboundmedicine.com/medl...s_and_Cognition

Cannabis is a First-Line Treatment for Childhood Mental Disorders
http://www.counterpunch.org/mikuriya07082006.html

Cannabis does not induce schizophrenia,
http://www.medicalnewstoday.com/articles/12283.php

Cannabis use does not cause schizophrenia
http://www.health.am/psy/more/canna..._schizophrenia/

Cannabinoids and psychosis.
http://www.ncbi.nlm.nih.gov/sites/e...Pubmed_RVDocSum

Cannabis as a psychotropic medication
http://bjp.rcpsych.org/cgi/content/full/185/1/78

Study Shows Long Term Marijuana Users Healthy
http://www.erowid.org/plants/cannab..._science3.shtml

Cannabis and schizophrenia link blurs further
http://www.newscientist.com/channel...rs-further.html

Evidence does not show a strong causal relation between the use of cannabis and psychosocial harm
http://www.library.nhs.uk/mentalHea...24106&tabID=289

Sickle Cell Disease
Cannabis Relieves Sickle Cell Disease!
http://www.cannabisculture.com/foru...?Number=1155878

Sickle Cell Disease and Cannabis
http://www.pacifier.com/~alive/cmu/Sickle_cell.htm

Marijuana smoking in young adults with sickle cell
http://caribbean.scielo.org/scielo....&lng=en&nrm=iso

Medical use of cannabis in sickle cell disease
http://www.chanvre-info.ch/info/it/...-in-sickle.html

Cannabis use in sickle cell disease: a questionnaire study.
http://www.ncbi.nlm.nih.gov/sites/e...2&dopt=Abstract

Sleep modulation
Cannabidiol, a constituent of Cannabis sativa, modulates sleep in rats.
http://www.medscape.com/medline/abs...844117?prt=true

Dronabinol reduces signs and symptoms of idiopathic intracranial hypertension
http://www.cannabis-med.org/studies...ow.php?s_id=181

Cannabis-based medicine in central pain in multiple sclerosis.
http://www.cannabis-med.org/studies...ow.php?s_id=175

Two cannabis based medicinal extracts for relief of central neuropathic pain
http://www.cannabis-med.org/studies...how.php?s_id=15

Functional role for cannabinoids in respiratory stability during sleep
http://www.pacifier.com/~alive/cmu/...sleep_apnea.htm

THC reduces sleep apnoea in animal research
http://www.cannabis-med.org/english...el.php?id=120#1

Spasticity
The treatment of spasticity with Delta(9)-tetrahydrocannabinol in persons with spinal cord injury.
http://www.cannabis-med.org/studies...ow.php?s_id=166

Cannabis-based medicine in spasticity caused by multiple sclerosis
http://www.cannabis-med.org/studies...ow.php?s_id=192

Cannabinoids in multiple sclerosis
http://www.cannabis-med.org/studies...ow.php?s_id=160

Sativex produced significant improvements in a subjective measure of spasticity
http://www.cannabis-med.org/studies...ow.php?s_id=170

Do cannabis-based medicinal extracts have general or specific effects on symptoms in ms?
http://www.cannabis-med.org/studies...how.php?s_id=56

Efficacy, safety and tolerability of an oral cannabis extract in the treatment of spasticity
http://www.cannabis-med.org/studies...how.php?s_id=63

Are oral cannabinoids safe and effective in refractory neuropathic pain?
http://www.cannabis-med.org/studies...ow.php?s_id=143

Experiences with THC-treatment in children and adolescents
http://www.cannabis-med.org/studies...how.php?s_id=80

The treatment of spasticity with D9-THC in patients with spinal cord injury
http://www.cannabis-med.org/studies...how.php?s_id=79

The effect of orally and rectally administered delta-9-tetrahydrocannabinol on spasticity
http://www.cannabis-med.org/studies...how.php?s_id=12

Nabilone in the treatment of multiple sclerosis.
http://www.cannabis-med.org/studies...how.php?s_id=11

Treatment of spasticity in spinal cord injury with dronabinol
http://www.cannabis-med.org/studies...ow.php?s_id=112

Delta-9-tetrahydrocannabinol shows antispastic and analgesic effects
http://www.cannabis-med.org/studies...how.php?s_id=10

Effect of cannabinoids on spasticity and ataxia in multiple sclerosis.
http://www.cannabis-med.org/studies...show.php?s_id=2

Delta-9-THC in the treatment of spasticity associated with multiple sclerosis.
http://www.cannabis-med.org/studies...show.php?s_id=1

Effect of Delta-9-THC on EMG Measurements in Human Spasticity
http://www.cannabis-med.org/studies...ow.php?s_id=110

The effect of delta-9-THC on human spasticity.
http://www.cannabis-med.org/studies...ow.php?s_id=154

Cannabis effect on spasticity in spinal cord injury.
http://www.cannabis-med.org/studies...ow.php?s_id=113

Treatment of human spasticity with delta 9-tetrahydrocannabinol.
http://www.cannabis-med.org/studies...show.php?s_id=8

Marihuana as a therapeutic agent for muscle spasm or spasticity.
http://www.cannabis-med.org/studies...how.php?s_id=53

The perceived effects of marijuana on spinal cord injured males.
http://www.cannabis-med.org/studies...ow.php?s_id=138

Motor effects of delta 9 THC in cerebellar Lurcher mutant mice.
http://www.unboundmedicine.com/medl...her_mutant_mice

Cannabis-based medicine in spasticity caused by multiple sclerosis
http://www.unboundmedicine.com/medl...tiple_sclerosis

Spinal Cord Injury
The treatment of spasticity with Delta(9)-tetrahydrocannabinol in persons with spinal cord injury.
http://www.cannabis-med.org/studies...ow.php?s_id=166

Are oral cannabinoids safe and effective in refractory neuropathic pain?
http://www.cannabis-med.org/studies...ow.php?s_id=143

The treatment of spasticity with D9-THC) in patients with spinal cord injury
http://www.cannabis-med.org/studies...how.php?s_id=79

Delta-9-THC as an alternative therapy for overactive bladders in spinal cord injury
http://www.cannabis-med.org/studies...ow.php?s_id=102

The effect of orally and rectally administered delta-9-tetrahydrocannabinol on spasticity
http://www.cannabis-med.org/studies...how.php?s_id=12

Treatment of spasticity in spinal cord injury with dronabinol
http://www.cannabis-med.org/studies...ow.php?s_id=112

Delta-9-tetrahydrocannabinol shows antispastic and analgesic effects
http://www.cannabis-med.org/studies...how.php?s_id=10

The effect of delta-9-THC on human spasticity.
http://www.cannabis-med.org/studies...ow.php?s_id=154

Cannabis effect on spasticity in spinal cord injury.
http://www.cannabis-med.org/studies...ow.php?s_id=113

Marihuana as a therapeutic agent for muscle spasm or spasticity.
http://www.cannabis-med.org/studies...how.php?s_id=53

The perceived effects of marijuana on spinal cord injured males.
http://www.cannabis-med.org/studies...ow.php?s_id=138

Stroke
Cannabidiol has a cerebroprotective action
http://www.unboundmedicine.com/medl...iting_mechanism

Delta(9)-THC) prevents cerebral infarction
http://www.unboundmedicine.com/medl...ent_hypothermia

Medical marijuana: study shows that THC slows atherosclerosis
http://thenexthurrah.typepad.com/th...al_marijua.html

Tea as medicine
Cannabis tea revisited: A systematic evaluation
http://www.ncbi.nlm.nih.gov/sites/e...Pubmed_RVDocSum

THC/tetrahydrocannabinol
THC is effective in the treatment of tics in Tourette syndrome
http://www.cannabis-med.org/studies...how.php?s_id=98

THC effective in Tourette-Syndrome
http://www.pacifier.com/~alive/cmu/tourette_thc.htm

THC effective in Tourette syndrome in a 6-week trial
http://www.cannabis-med.org/english...el.php?id=146#1

Treatment of Tourette's Syndrome With Delta-9-Tetrahydrocannabinol
http://ajp.psychiatryonline.org/cgi.../full/156/3/495

THC inhibits primary marker of Alzheimer's disease
http://www.cannabis-med.org/english...el.php?id=225#3

THC improves appetite and reverses weight loss in AIDS patients
http://www.cannabis-med.org/studies...ow.php?s_id=189

Cancer-related anorexia-cachexia syndrome
http://www.unboundmedicine.com/medl...xia_Study_Group

THC effective in appetite and weight loss in severe lung disease (COPD)
http://www.cannabis-med.org/english...el.php?id=191#2

The antinociceptive effect of Delta9-tetrahydrocannabinol in the arthritic rat
http://www.unboundmedicine.com/medl...binoid_receptor

Synergy between Delta(9)-tetrahydrocannabinol and morphine in the arthritic rat
http://www.unboundmedicine.com/medl...e_arthritic_rat

Bronchial effects of aerosolized delta 9-tetrahydrocannabinol
http://www.cannabis-med.org/studies...ow.php?s_id=109

Bronchodilator effect of delta1-tetrahydrocannabinol administered by aerosol
http://www.cannabis-med.org/studies...how.php?s_id=60

Effects of smoked marijuana in experimentally induced asthma.
http://www.cannabis-med.org/studies...how.php?s_id=57

Marijuana and oral delta9-tetrahydrocannabinol on specific airway conductance
http://www.cannabis-med.org/studies...how.php?s_id=67

New Synthetic Delta-9-THC Inhaler Offers Safe, Rapid Delivery
http://www.medicalnewstoday.com/articles/22937.php

Smoked marijuana and oral delta-9-THC on specific airway conductance in asthmatic subjects
http://www.ukcia.org/research/Smoke...InAsthmatic.php

Delta(9)-tetrahydrocannabinol in patients with recurrent glioblastoma multiforme.
http://www.cannabis-med.org/studies...ow.php?s_id=193

9-Tetrahydrocannabinol Inhibits Cell Cycle Progression in Human Breast Cancer
http://cancerres.aacrjournals.org/c...ract/66/13/6615

THC and prochlorperazine effective in reducing vomiting in women following breast surgery
http://www.cannabis-med.org/english...el.php?id=219#1

{Delta}9-Tetrahydrocannabinol-Induced Apoptosis in Jurkat Leukemia T Cells
http://mcr.aacrjournals.org/cgi/con...bstract/4/8/549

Delta(9)-THC) prevents cerebral infarction
http://www.unboundmedicine.com/medl...ent_hypothermia

Medical marijuana: study shows that THC slows atherosclerosis
http://thenexthurrah.typepad.com/th...al_marijua.html
Delta-9-tetrahydrocannabinol shows antispastic and analgesic effects
http://www.cannabis-med.org/studies...how.php?s_id=10

The effect of delta-9-THC on human spasticity.
http://www.cannabis-med.org/studies...ow.php?s_id=154

The treatment of spasticity with D9-THC) in patients with spinal cord injury
http://www.cannabis-med.org/studies...how.php?s_id=79

Delta-9-THC as an alternative therapy for overactive bladders in spinal cord injury
http://www.cannabis-med.org/studies...ow.php?s_id=102

The effect of orally and rectally administered delta-9-tetrahydrocannabinol on spasticity
http://www.cannabis-med.org/studies...how.php?s_id=12

The treatment of spasticity with Delta(9)-tetrahydrocannabinol in persons with spinal cord injury.
http://www.cannabis-med.org/studies...ow.php?s_id=166

Delta-9-Tetrahydrocannabinol-Induced Effects on Psychosis and Cognition
http://www.unboundmedicine.com/medl...s_and_Cognition

The effect of orally and rectally administered delta-9-tetrahydrocannabinol on spasticity
http://www.cannabis-med.org/studies...how.php?s_id=12

Marihuana as a therapeutic agent for muscle spasm or spasticity.
http://www.cannabis-med.org/studies...how.php?s_id=53

Analgesic effect of delta-9-tetrahydrocannabinol.
http://www.cannabis-med.org/studies...how.php?s_id=16

The analgesic properties of delta-9-tetrahydrocannabinol and codeine.
http://www.cannabis-med.org/studies...how.php?s_id=17

The perceived effects of smoked cannabis on patients with multiple sclerosis.
http://www.cannabis-med.org/studies...how.php?s_id=13

Cannabis use for chronic non-cancer pain
http://www.cannabis-med.org/studies...how.php?s_id=91

Tetrahydrocannabinol for treatment of chronic pain
http://www.cannabis-med.org/studies...ow.php?s_id=147

Delta-9-THC based monotherapy in fibromyalgia patients
http://www.cannabis-med.org/studies...ow.php?s_id=194

Delta(9)-THC) prevents cerebral infarction
http://www.unboundmedicine.com/medl...ent_hypothermia

Delta(9)-Tetrahydrocannabinol protects hippocampal neurons from excitotoxicity
http://www.unboundmedicine.com/medl..._excitotoxicity

Tobacco vs Cannabis- 
Cannabis Smoke and Cancer: Assessing the Risk
http://www.norml.org/index.cfm?Group_ID=6891

Cannabis and tobacco smoke are not equally carcinogenic
http://www.pubmedcentral.nih.gov/ar...i?artid=1277837

Smoking Marijuana Does Not Cause Lung Cancer
http://www.mapinc.org/drugnews/v05/n1065/a03.html

Tobacco and marijuana use on offspring growth from birth through 3 years of age.
http://www.ncbi.nlm.nih.gov/sites/e...Pubmed_RVDocSum

Progression from marijuana use to daily smoking and nicotine dependence
http://www.erowid.org/references/refs_view.php?ID=6951

High anxieties - What the WHO doesn't want you to know about cannabis
http://www.newscientist.com/article...t-cannabis.html

Radioactive tobacco
http://www.cannabisculture.com/news/tobacco/

Tourette’s Syndrome
Treatment of Tourette's Syndrome With Delta-9-Tetrahydrocannabinol
http://ajp.psychiatryonline.org/cgi.../full/156/3/495

THC is effective in the treatment of tics in Tourette syndrome
http://www.cannabis-med.org/studies...how.php?s_id=98

Treatment of Tourette's syndrome with Delta 9-tetrahydrocannabinol
http://www.cannabis-med.org/studies...how.php?s_id=99

Cannabinoids: possible role in patho-physiology and therapy of Gilles de la Tourette syndrome.
http://www.cannabis-med.org/studies...ow.php?s_id=100

THC effective in Tourette-Syndrome
http://www.pacifier.com/~alive/cmu/tourette_thc.htm

THC effective in Tourette syndrome in a 6-week trial
http://www.cannabis-med.org/english...el.php?id=146#1

Vaporizers
Vaporization as a smokeless cannabis delivery system
http://www.cannabis-med.org/studies...ow.php?s_id=187

Smokeless Cannabis Delivery Device Efficient And Less Toxic
http://www.medicalnewstoday.com/articles/71112.php

Volcano is to Vaporizer As Porsche is to Automobile
http://ccrmg.org/journal/04spr/volcano.html

Recommendation to Patients: "Don’t smoke, Vaporize"
http://ccrmg.org/journal/03sum/vaporize.html

Decreased respiratory symptoms in cannabis users who vaporize.
http://marijuana.researchtoday.net/archive/4/4/1195.htm

Use of vaporizers reduces toxins from cannabis smoke
http://www.cannabis-med.org/english...el.php?id=146#2

Wilson’s Disease
Cannabis sativa and dystonia secondary to Wilson's disease.
http://www.medscape.com/medline/abstract/15390041